CCNC_MOUSE
ID CCNC_MOUSE Reviewed; 283 AA.
AC Q62447; Q0P542; Q5XKQ9; Q9WUZ4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 4.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Cyclin-C;
GN Name=Ccnc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Chi P., Mifflin R., Thompson E.A.;
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
RA Barette C., Dulic V., Piette J.;
RT "Transcription of the cyclin C gene.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated gene transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. Binds to and activates cyclin-
CC dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain)
CC of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC the formation of a transcription initiation complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC module termed the CDK8 module. Mediator containing the CDK8 module is
CC less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed
CC by CCNC/CDK8 also associates with the large subunit of RNA polymerase
CC II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; U62638; AAB05260.1; -; mRNA.
DR EMBL; U49050; AAD11444.1; -; Genomic_DNA.
DR EMBL; AL772187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466538; EDL05561.1; -; Genomic_DNA.
DR EMBL; BC003344; AAH03344.2; -; mRNA.
DR EMBL; BC120649; AAI20650.1; -; mRNA.
DR EMBL; BC120677; AAI20678.1; -; mRNA.
DR EMBL; AJ243075; CAB45390.1; -; Genomic_DNA.
DR EMBL; AJ243076; CAB45390.1; JOINED; Genomic_DNA.
DR CCDS; CCDS17998.1; -.
DR RefSeq; NP_001277351.1; NM_001290422.1.
DR RefSeq; NP_058026.2; NM_016746.4.
DR AlphaFoldDB; Q62447; -.
DR SMR; Q62447; -.
DR BioGRID; 206188; 3.
DR ComplexPortal; CPX-3266; CKM complex variant 1.
DR ComplexPortal; CPX-3267; CKM complex variant 2.
DR ComplexPortal; CPX-331; Cyclin C-CDK3 complex.
DR CORUM; Q62447; -.
DR DIP; DIP-61081N; -.
DR IntAct; Q62447; 4.
DR STRING; 10090.ENSMUSP00000100062; -.
DR BindingDB; Q62447; -.
DR ChEMBL; CHEMBL4296068; -.
DR PhosphoSitePlus; Q62447; -.
DR EPD; Q62447; -.
DR MaxQB; Q62447; -.
DR PaxDb; Q62447; -.
DR PRIDE; Q62447; -.
DR ProteomicsDB; 281127; -.
DR Antibodypedia; 4188; 360 antibodies from 32 providers.
DR DNASU; 51813; -.
DR Ensembl; ENSMUST00000102997; ENSMUSP00000100062; ENSMUSG00000028252.
DR GeneID; 51813; -.
DR KEGG; mmu:51813; -.
DR UCSC; uc008scu.3; mouse.
DR CTD; 892; -.
DR MGI; MGI:1858199; Ccnc.
DR VEuPathDB; HostDB:ENSMUSG00000028252; -.
DR eggNOG; KOG0794; Eukaryota.
DR GeneTree; ENSGT00940000155625; -.
DR InParanoid; Q62447; -.
DR OMA; SHHQQWL; -.
DR OrthoDB; 1079428at2759; -.
DR PhylomeDB; Q62447; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR Reactome; R-MMU-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR BioGRID-ORCS; 51813; 23 hits in 76 CRISPR screens.
DR ChiTaRS; Ccnc; mouse.
DR PRO; PR:Q62447; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q62447; protein.
DR Bgee; ENSMUSG00000028252; Expressed in ectoplacental cone and 253 other tissues.
DR ExpressionAtlas; Q62447; baseline and differential.
DR Genevisible; Q62447; MM.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISO:MGI.
DR GO; GO:0016592; C:mediator complex; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0000151; C:ubiquitin ligase complex; ISO:MGI.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISO:MGI.
DR GO; GO:0045023; P:G0 to G1 transition; ISO:MGI.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:MGI.
DR GO; GO:0090209; P:negative regulation of triglyceride metabolic process; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Activator; Cyclin; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..283
FT /note="Cyclin-C"
FT /id="PRO_0000080421"
FT DOMAIN 20..151
FT /note="Cyclin N-terminal"
FT REGION 252..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 275
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P24863"
FT CONFLICT 73
FT /note="Y -> D (in Ref. 1; AAB05260)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 33241 MW; DE2065E2E4C304FC CRC64;
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA ATTSVLKTRF
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED VLLPLAWRIV
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS
