ID   CCNC_RAT                Reviewed;         278 AA.
AC   P39947;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Cyclin-C;
GN   Name=Ccnc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   PubMed=8336937;
RA   Tamura K., Kanaoka Y., Jinno S., Nagata A., Ogiso Y., Shimizu K.,
RA   Hayakawa T., Nojima H., Okayama H.;
RT   "Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1.";
RL   Oncogene 8:2113-2118(1993).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed
CC       by CCNC/CDK8 also associates with the large subunit of RNA polymerase
CC       II (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA03114.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D14013; BAA03114.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; P39947; -.
DR   SMR; P39947; -.
DR   STRING; 10116.ENSRNOP00000011442; -.
DR   PaxDb; P39947; -.
DR   UCSC; RGD:70905; rat.
DR   RGD; 70905; Ccnc.
DR   eggNOG; KOG0794; Eukaryota.
DR   InParanoid; P39947; -.
DR   PRO; PR:P39947; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISO:RGD.
DR   GO; GO:0016592; C:mediator complex; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IDA:RGD.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0045023; P:G0 to G1 transition; ISO:RGD.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:RGD.
DR   GO; GO:0090209; P:negative regulation of triglyceride metabolic process; IMP:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IDA:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Activator; Cyclin; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..278
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000080422"
FT   DOMAIN          41..139
FT                   /note="Cyclin N-terminal"
FT   REGION          247..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         270
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P24863"
SQ   SEQUENCE   278 AA;  32514 MW;  A8A0EDC18E7FCBE4 CRC64;
     MAGNFWQSSH YLQWILDKER QKDLKFLSEE EYWKLQIFFT NVIQALGEHL KLRQQVIATA
     TVYFKRFYAR YSLKSIDPVL MAPTCVFLAS KVEEFGVVSN TSLIAATTSV LKTRFSYASP
     KEFPYRMNHI LECEFYLLEL MDCCLIVYHP YRPLLQYVQD MGQEDVLLPL AWRIVNDTYR
     TDLCLLYPPF MIALACLHVA CVVQQKDARQ WFAELSVDME KILEIIRVIL KLYEQWKNFD
     ERKEMATILS KMPKPKPPPN SEGEQGPNGS QNSSYSQS