CCNC_XENLA
ID CCNC_XENLA Reviewed; 283 AA.
AC Q4KLA0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Cyclin-C;
GN Name=ccnc;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated gene transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. Binds to and activates cyclin-
CC dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain)
CC of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC the formation of a transcription initiation complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. The cylin/CDK pair formed
CC by ccnc/cdk8 also associates with the large subunit of RNA polymerase
CC II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; BC099287; AAH99287.1; -; mRNA.
DR EMBL; BC099330; AAH99330.1; -; mRNA.
DR RefSeq; NP_001089618.1; NM_001096149.1.
DR AlphaFoldDB; Q4KLA0; -.
DR SMR; Q4KLA0; -.
DR MaxQB; Q4KLA0; -.
DR DNASU; 734677; -.
DR GeneID; 734677; -.
DR KEGG; xla:734677; -.
DR CTD; 734677; -.
DR Xenbase; XB-GENE-922018; ccnc.L.
DR OMA; MSGSYWT; -.
DR OrthoDB; 1079428at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 734677; Expressed in ovary and 19 other tissues.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..283
FT /note="Cyclin-C"
FT /id="PRO_0000314258"
FT DOMAIN 46..144
FT /note="Cyclin N-terminal"
FT REGION 252..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 33178 MW; 22E6BA13A7AA4797 CRC64;
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIS AATSVLKTRF
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
WKNFDERKEM ASILSKMPKP KPPPNSDGEQ GTNGSQSSGY SQS
