ID   CCNC_XENTR              Reviewed;         283 AA.
AC   Q28F72; Q6P7L7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Cyclin-C;
GN   Name=ccnc; ORFNames=TGas144o20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. The cylin/CDK pair formed
CC       by ccnc/cdk8 also associates with the large subunit of RNA polymerase
CC       II (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH61613.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR762131; CAJ81984.1; -; mRNA.
DR   EMBL; BC061613; AAH61613.1; ALT_INIT; mRNA.
DR   RefSeq; NP_989157.2; NM_203826.2.
DR   AlphaFoldDB; Q28F72; -.
DR   SMR; Q28F72; -.
DR   STRING; 8364.ENSXETP00000055094; -.
DR   PaxDb; Q28F72; -.
DR   DNASU; 394762; -.
DR   Ensembl; ENSXETT00000055094; ENSXETP00000055094; ENSXETG00000026026.
DR   GeneID; 394762; -.
DR   KEGG; xtr:394762; -.
DR   CTD; 892; -.
DR   Xenbase; XB-GENE-922006; ccnc.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_1_1_1; -.
DR   InParanoid; Q28F72; -.
DR   OMA; MSGSYWT; -.
DR   OrthoDB; 1079428at2759; -.
DR   PhylomeDB; Q28F72; -.
DR   Reactome; R-XTR-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026026; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR028367; CyclinC/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Activator; Cyclin; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000314259"
FT   DOMAIN          46..144
FT                   /note="Cyclin N-terminal"
FT   REGION          252..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  33233 MW;  6278DA13BB7B8A90 CRC64;
     MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
     VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIS AATSVLKTRF
     SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED MLLPLAWRIV
     NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
     WKNFDERKEM ATILNKMPKP KPPPNSEGEQ GTNGSQSSGY SQS