ID   CCND1_DANRE             Reviewed;         291 AA.
AC   Q90459;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=G1/S-specific cyclin-D1;
GN   Name=ccnd1; Synonyms=cycd1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8547308; DOI=10.1016/0167-4781(95)00175-1;
RA   Yarden A., Salomon D., Geiger B.;
RT   "Zebrafish cyclin D1 is differentially expressed during early
RT   embryogenesis.";
RL   Biochim. Biophys. Acta 1264:257-260(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that
CC       phosphorylates and inhibits members of the retinoblastoma (RB) protein
CC       family including RB1 and regulates the cell-cycle during G(1)/S
CC       transition. Phosphorylation of RB1 allows dissociation of the
CC       transcription factor E2F from the RB/E2F complex and the subsequent
CC       transcription of E2F target genes which are responsible for the
CC       progression through the G(1) phase. Hypophosphorylates RB1 in early
CC       G(1) phase. Cyclin D-CDK4 complexes are major integrators of various
CC       mitogenenic and antimitogenic signals. {ECO:0000250|UniProtKB:P24385}.
CC   -!- SUBUNIT: Interacts with the CDK4 and CDK6 protein kinases to form a
CC       serine/threonine kinase holoenzyme complex (By similarity). The cyclin
CC       subunit imparts substrate specificity to the complex (By similarity).
CC       {ECO:0000250|UniProtKB:P24385}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P24385}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P24385}.
CC   -!- PTM: Phosphorylation at Thr-282 by MAP kinases is required for
CC       ubiquitination and degradation by the DCX(AMBRA1) complex.
CC       {ECO:0000250|UniProtKB:P24385}.
CC   -!- PTM: Ubiquitinated by the DCX(AMBRA1) complex during the transition
CC       from G1 to S cell phase, leading to its degradation. The DCX(AMBRA1)
CC       complex represents the major regulator of CCND1 stability during the
CC       G1/S transition. {ECO:0000250|UniProtKB:P24385}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X87581; CAA60885.1; -; mRNA.
DR   EMBL; BC075743; AAH75743.1; -; mRNA.
DR   PIR; S62730; S62730.
DR   RefSeq; NP_571100.1; NM_131025.4.
DR   AlphaFoldDB; Q90459; -.
DR   SMR; Q90459; -.
DR   STRING; 7955.ENSDARP00000051867; -.
DR   PaxDb; Q90459; -.
DR   Ensembl; ENSDART00000163748; ENSDARP00000140550; ENSDARG00000101637.
DR   Ensembl; ENSDART00000165320; ENSDARP00000134435; ENSDARG00000101637.
DR   GeneID; 30222; -.
DR   KEGG; dre:30222; -.
DR   CTD; 595; -.
DR   ZFIN; ZDB-GENE-980526-176; ccnd1.
DR   eggNOG; KOG0656; Eukaryota.
DR   GeneTree; ENSGT00940000157816; -.
DR   HOGENOM; CLU_052190_0_0_1; -.
DR   InParanoid; Q90459; -.
DR   OMA; SCYRTTH; -.
DR   OrthoDB; 1234739at2759; -.
DR   PhylomeDB; Q90459; -.
DR   TreeFam; TF101004; -.
DR   Reactome; R-DRE-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR   Reactome; R-DRE-3214858; RMTs methylate histone arginines.
DR   Reactome; R-DRE-69231; Cyclin D associated events in G1.
DR   Reactome; R-DRE-75815; Ubiquitin-dependent degradation of Cyclin D.
DR   Reactome; R-DRE-8849470; PTK6 Regulates Cell Cycle.
DR   Reactome; R-DRE-8878166; Transcriptional regulation by RUNX2.
DR   Reactome; R-DRE-8934593; Regulation of RUNX1 Expression and Activity.
DR   Reactome; R-DRE-8951936; RUNX3 regulates p14-ARF.
DR   Reactome; R-DRE-9754119; Drug-mediated inhibition of CDK4/CDK6 activity.
DR   PRO; PR:Q90459; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000101637; Expressed in gastrula and 65 other tissues.
DR   ExpressionAtlas; Q90459; baseline and differential.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0017053; C:transcription repressor complex; ISS:UniProtKB.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR   GO; GO:0048593; P:camera-type eye morphogenesis; IMP:ZFIN.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0031571; P:mitotic G1 DNA damage checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0070050; P:neuron cellular homeostasis; IMP:ZFIN.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0061074; P:regulation of neural retina development; IGI:ZFIN.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR015451; Cyclin_D.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   PANTHER; PTHR10177:SF67; PTHR10177:SF67; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00292; CYCLINS; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cyclin; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..291
FT                   /note="G1/S-specific cyclin-D1"
FT                   /id="PRO_0000080435"
FT   MOD_RES         282
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P24385"
SQ   SEQUENCE   291 AA;  33067 MW;  FA5274CB1B46D5EF CRC64;
     MEHQLFCCEV DTIRRAYQDS NLLNDRVLQT MLKAEENYLP SPNYFKCVQK EIVPKMRKIV
     ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS VEPTKKTRLQ LLGATCMFLA SKMKETVPLT
     AEKLCIYTDN SVRPGELLQM ELLALNKLKW DLASVTPHDF IEHFLAKLPI HQSSKQILRK
     HAQTFVALCA TDVNFIASPP SMIAAGSVAA AVQGLYLKST DSCLSSQNLT NFLSQVIRSD
     PDCLRSCQEQ IESLLESSLR QAQQHISTET KRVEEDVDLS CTPTDVRDIN I