CCND_CAEEL
ID CCND_CAEEL Reviewed; 405 AA.
AC Q9U2M5; O77085;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=G1/S-specific cyclin-D {ECO:0000305};
GN Name=cyd-1 {ECO:0000312|WormBase:Y38F1A.5};
GN ORFNames=Y38F1A.5 {ECO:0000312|WormBase:Y38F1A.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAC35273.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CDK-4, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=10518501; DOI=10.1242/dev.126.21.4849;
RA Park M., Krause M.W.;
RT "Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis
RT elegans by a cyclin D/CDK-like complex.";
RL Development 126:4849-4860(1999).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11684669; DOI=10.1242/dev.128.21.4349;
RA Boxem M., van den Heuvel S.;
RT "lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1
RT progression in C. elegans.";
RL Development 128:4349-4359(2001).
RN [4] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15708572; DOI=10.1016/j.ydbio.2004.12.022;
RA Yanowitz J., Fire A.;
RT "Cyclin D involvement demarcates a late transition in C. elegans
RT embryogenesis.";
RL Dev. Biol. 279:244-251(2005).
RN [5] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF ALA-205.
RX PubMed=16198291; DOI=10.1016/j.devcel.2005.09.004;
RA Tilmann C., Kimble J.;
RT "Cyclin D regulation of a sexually dimorphic asymmetric cell division.";
RL Dev. Cell 9:489-499(2005).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25562820; DOI=10.1038/ncomms6906;
RA The I., Ruijtenberg S., Bouchet B.P., Cristobal A., Prinsen M.B.,
RA van Mourik T., Koreth J., Xu H., Heck A.J., Akhmanova A., Cuppen E.,
RA Boxem M., Munoz J., van den Heuvel S.;
RT "Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and
RT human cancer cells.";
RL Nat. Commun. 6:5906-5906(2015).
CC -!- FUNCTION: In association with cdk-4, regulates the progression through
CC the G1 phase of the cell cycle during postembryonic development
CC (PubMed:10518501, PubMed:11684669, PubMed:25562820). Regulates
CC proliferation of the coelomocyte lineage and intestinal cells during
CC late embryogenesis (PubMed:15708572, PubMed:11684669). In complex with
CC cdk-4, involved in sex determination during gonadogenesis by regulating
CC the asymmetric division of the somatic gonadal precursor cell (SGP)
CC (PubMed:16198291). {ECO:0000269|PubMed:10518501,
CC ECO:0000269|PubMed:11684669, ECO:0000269|PubMed:15708572,
CC ECO:0000269|PubMed:16198291, ECO:0000269|PubMed:25562820}.
CC -!- SUBUNIT: Interacts with cdk-4; the interaction is likely involved in
CC regulating cdk-4 activity (PubMed:10518501).
CC {ECO:0000269|PubMed:10518501}.
CC -!- INTERACTION:
CC Q9U2M5; Q9XTR1: cdk-4; NbExp=2; IntAct=EBI-2420074, EBI-14063019;
CC -!- DEVELOPMENTAL STAGE: Expression initiates during mid-embryogenesis
CC primarily in post-proliferative hypodermal cells and neurons in the
CC head, ventral cord and tail, then declines until hatching where it is
CC mainly seen in seam cells. Expressed throughout larval development in
CC several blast cell linages. In the P lineage, expression is restricted
CC to proliferating cells, whereas it persists in somatic gonads and seam
CC cells. In somatic gonads, expression is restricted to the spermathecal
CC cells and their precursors. Not expressed in the intestine.
CC {ECO:0000269|PubMed:10518501}.
CC -!- DISRUPTION PHENOTYPE: Arrested cell division in the G1 phase during
CC larval development (PubMed:25562820). RNAi-mediated knockdown results
CC in an arrest at L2 stage which is associated with uncoordinated
CC movements, a slightly shorter and stouter body morphology, growth
CC arrest and premature death (PubMed:10518501). In addition, during
CC larval development, cell division is impaired in P blast cells and
CC mesoblast M cells due to an arrest prior to S phase (PubMed:10518501).
CC Lack of cell division in somatic gonad precursors Z1 and Z4 which is
CC associated with a failure to maintain germline proliferation resulting
CC in an abnormal gonad development (PubMed:10518501). At the late
CC embryonic stage, intestinal cells fail to divide without affecting
CC endoreduplication which results in 4n DNA cellular content
CC (PubMed:11684669). Mutants show slightly stronger defects including the
CC development of only two enlarged embryonic coelomocytes
CC (PubMed:11684669, PubMed:15708572). Double knockout with lin-35 rescues
CC the cell cycle progression defect in the single cyd-1 mutant
CC (PubMed:11684669, PubMed:25562820). {ECO:0000269|PubMed:10518501,
CC ECO:0000269|PubMed:11684669, ECO:0000269|PubMed:15708572,
CC ECO:0000269|PubMed:25562820}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
CC {ECO:0000305}.
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DR EMBL; AF053067; AAC35273.1; -; mRNA.
DR EMBL; BX284602; CAA21630.1; -; Genomic_DNA.
DR PIR; T26678; T26678.
DR PIR; T42992; T42992.
DR RefSeq; NP_496763.1; NM_064362.5.
DR AlphaFoldDB; Q9U2M5; -.
DR SMR; Q9U2M5; -.
DR ComplexPortal; CPX-1126; Cyclin cyd-1-cdk4 complex.
DR IntAct; Q9U2M5; 2.
DR STRING; 6239.Y38F1A.5.2; -.
DR PaxDb; Q9U2M5; -.
DR EnsemblMetazoa; Y38F1A.5.1; Y38F1A.5.1; WBGene00000870.
DR EnsemblMetazoa; Y38F1A.5.2; Y38F1A.5.2; WBGene00000870.
DR GeneID; 174941; -.
DR UCSC; Y38F1A.5.1; c. elegans.
DR CTD; 174941; -.
DR WormBase; Y38F1A.5; CE21610; WBGene00000870; cyd-1.
DR eggNOG; KOG0656; Eukaryota.
DR GeneTree; ENSGT00940000168741; -.
DR HOGENOM; CLU_680145_0_0_1; -.
DR InParanoid; Q9U2M5; -.
DR OMA; NCMEYEE; -.
DR OrthoDB; 1185063at2759; -.
DR PhylomeDB; Q9U2M5; -.
DR Reactome; R-CEL-1538133; G0 and Early G1.
DR Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-CEL-2559586; DNA Damage/Telomere Stress Induced Senescence.
DR Reactome; R-CEL-6804116; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
DR Reactome; R-CEL-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-CEL-69200; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
DR Reactome; R-CEL-69202; Cyclin E associated events during G1/S transition.
DR Reactome; R-CEL-69563; p53-Dependent G1 DNA Damage Response.
DR PRO; PR:Q9U2M5; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000870; Expressed in embryo and 3 other tissues.
DR GO; GO:0097128; C:cyclin D1-CDK4 complex; IPI:ComplexPortal.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0008356; P:asymmetric cell division; IMP:UniProtKB.
DR GO; GO:0044843; P:cell cycle G1/S phase transition; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:ComplexPortal.
DR GO; GO:0008406; P:gonad development; IGI:UniProtKB.
DR GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR GO; GO:0040035; P:hermaphrodite genitalia development; IMP:UniProtKB.
DR GO; GO:0008584; P:male gonad development; IMP:UniProtKB.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0051782; P:negative regulation of cell division; IMP:UniProtKB.
DR GO; GO:0002119; P:nematode larval development; IMP:UniProtKB.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:UniProtKB.
DR GO; GO:1904787; P:positive regulation of asymmetric protein localization involved in cell fate determination; IMP:UniProtKB.
DR GO; GO:0090727; P:positive regulation of brood size; IMP:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IMP:UniProtKB.
DR GO; GO:0032877; P:positive regulation of DNA endoreduplication; IMP:UniProtKB.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:1902806; P:regulation of cell cycle G1/S phase transition; IGI:UniProtKB.
DR GO; GO:0051302; P:regulation of cell division; IGI:UniProtKB.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IGI:UniProtKB.
DR GO; GO:0007530; P:sex determination; IMP:UniProtKB.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Differentiation;
KW Gonadal differentiation; Reference proteome.
FT CHAIN 1..405
FT /note="G1/S-specific cyclin-D"
FT /evidence="ECO:0000305"
FT /id="PRO_0000433404"
FT DOMAIN 76..200
FT /note="Cyclin N-terminal"
FT /evidence="ECO:0000255"
FT REGION 301..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 205
FT /note="A->T: In q626; in both hermaphrodites and males,
FT impaired gonad development due to a failure to generate
FT distal tip cells (DTC)."
FT /evidence="ECO:0000269|PubMed:16198291"
FT CONFLICT 210
FT /note="D -> N (in Ref. 1; AAC35273)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="M -> T (in Ref. 1; AAC35273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 405 AA; 45766 MW; 15339201B7D031AE CRC64;
MDFESSSAGP STSYAEEPCT LSMLPQVSAV LSETSITESN VSCQLHPSRS AALNDNVRTL
IYNRTDPHIQ LDMRAFYNCM EYEEALQPNY HYFTGVQENI TPFHREQAID WIYDVAKEEN
CDGDVFLLAV SLIDRFMSVQ NILKHDIQMI AGVALFIASK LKAPHPMTAS KIAYYSDNSC
PIDMILQWEL LIVTTLQWET ESPTAFSFFD FLASRIPQIH NMRGDFQTVV QKCQKMHKLA
TLFPSMQCAI GLYYVSNLPT QNKELAVKIK DLLANMFQLE VNLLDSYIPM VQRCMSTTPI
YTSEDAEKTE PTPSAPASTQ EPEAFQELKE LKEEPLPTPP PEEPAFQKLV LLEPIPLSEQ
TPSTPLNDSG FSSDVSSPAS SEKKRRRSTD WFEEDSTPPK IFKTL
