ID   CCNG1_RAT               Reviewed;         294 AA.
AC   P39950;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Cyclin-G1;
DE            Short=Cyclin-G;
GN   Name=Ccng1; Synonyms=Ccng;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fibroblast;
RX   PubMed=8336937;
RA   Tamura K., Kanaoka Y., Jinno S., Nagata A., Ogiso Y., Shimizu K.,
RA   Hayakawa T., Nojima H., Okayama H.;
RT   "Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1.";
RL   Oncogene 8:2113-2118(1993).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RX   PubMed=8954786; DOI=10.1006/geno.1996.0598;
RA   Endo Y., Fujita T., Tamura K., Tsuruga H., Nojima H.;
RT   "Structure and chromosomal assignment of the human cyclin G gene.";
RL   Genomics 38:92-95(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Fischer; TISSUE=Embryonic fibroblast;
RX   PubMed=7784084;
RA   Zauberman A., Lupo A., Oren M.;
RT   "Identification of p53 target genes through immune selection of genomic
RT   DNA: the cyclin G gene contains two distinct p53 binding sites.";
RL   Oncogene 10:2361-2366(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION.
RX   PubMed=9464250; DOI=10.1006/bbrc.1997.8004;
RA   Shimizu A., Nishida J., Ueoka Y., Kato K., Hachiya T., Kuriaki Y., Wake N.;
RT   "CyclinG contributes to G2/M arrest of cells in response to DNA damage.";
RL   Biochem. Biophys. Res. Commun. 242:529-533(1998).
CC   -!- FUNCTION: May play a role in growth regulation. Is associated with G2/M
CC       phase arrest in response to DNA damage. May be an intermediate by which
CC       p53 mediates its role as an inhibitor of cellular proliferation.
CC       {ECO:0000269|PubMed:9464250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Induced within 3 hours after growth stimulation,
CC       remains elevated with no apparent cell cycle dependency.
CC   -!- INDUCTION: By doxorubicin (DOX).
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X70871; CAA50219.1; -; mRNA.
DR   EMBL; BC081852; AAH81852.1; -; mRNA.
DR   PIR; S37693; S37693.
DR   RefSeq; NP_037055.1; NM_012923.2.
DR   AlphaFoldDB; P39950; -.
DR   SMR; P39950; -.
DR   BioGRID; 247440; 2.
DR   STRING; 10116.ENSRNOP00000063905; -.
DR   PaxDb; P39950; -.
DR   Ensembl; ENSRNOT00000065633; ENSRNOP00000063905; ENSRNOG00000003256.
DR   GeneID; 25405; -.
DR   KEGG; rno:25405; -.
DR   UCSC; RGD:2295; rat.
DR   CTD; 900; -.
DR   RGD; 2295; Ccng1.
DR   eggNOG; KOG0653; Eukaryota.
DR   GeneTree; ENSGT00940000154726; -.
DR   HOGENOM; CLU_062642_0_0_1; -.
DR   InParanoid; P39950; -.
DR   OrthoDB; 1015714at2759; -.
DR   PhylomeDB; P39950; -.
DR   TreeFam; TF101007; -.
DR   Reactome; R-RNO-6804757; Regulation of TP53 Degradation.
DR   PRO; PR:P39950; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000003256; Expressed in quadriceps femoris and 20 other tissues.
DR   ExpressionAtlas; P39950; baseline and differential.
DR   Genevisible; P39950; RN.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IMP:RGD.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0009629; P:response to gravity; IEP:RGD.
DR   GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR   GO; GO:0006949; P:syncytium formation; IMP:RGD.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR028860; CCNG1.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   PANTHER; PTHR10177:SF59; PTHR10177:SF59; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cyclin; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..294
FT                   /note="Cyclin-G1"
FT                   /id="PRO_0000080468"
SQ   SEQUENCE   294 AA;  33934 MW;  229A5588E66F0DBC CRC64;
     MIEVLTTDSQ KLLHQLNTLL EQESRCQPKV CGLKLIESAH DNGLRMTARL RDFEVKDLLS
     LTQFFGFDTE TFSLAVNLLD RFLSKMKVQA KHLGCVGLSC FYLAVKSIEE ERNVPLATDL
     IRISQYRFTV SDLMRMEKIV LEKVCWKVKA TTAFQFLQLY YSLIRETLPF ERRNDLNFER
     LEAQLKACHC RIIFSKAKPS VLALAIIALE IQALKYVELT EGVECIQKHS KISGRDLTFW
     QELVSKCLTE YSSNKCSKPN GQKLKWIVSG RTARQLKHSY YRITHLPTIP ETMG