CCNG2_HUMAN
ID CCNG2_HUMAN Reviewed; 344 AA.
AC Q16589; B4DF25; Q6FGA7; Q6FGC6;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Cyclin-G2;
GN Name=CCNG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain, and Fetal spleen;
RX PubMed=8806701;
RA Bates S.A., Rowan S., Vousden K.H.;
RT "Characterisation of human cyclin G1 and G2: DNA damage inducible genes.";
RL Oncogene 13:1103-1109(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=T-cell;
RX PubMed=8626390; DOI=10.1074/jbc.271.11.6050;
RA Horne M.C., Goolsby G.L., Donaldson K.L., Tran D., Neubauer M.G.,
RA Wahl A.F.;
RT "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting
RT tissue-specific and cell cycle-regulated expression.";
RL J. Biol. Chem. 271:6050-6061(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-4 AND GLY-28.
RG NIEHS SNPs program;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in growth regulation and in negative
CC regulation of cell cycle progression.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q16589-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q16589-2; Sequence=VSP_053893;
CC -!- TISSUE SPECIFICITY: High levels in cerebellum, thymus, spleen and
CC prostate. Low levels in skeletal muscle.
CC -!- DEVELOPMENTAL STAGE: Expression levels increase through the cell cycle
CC to peak in the mid/late-S phase and decrease during G2/M phase.
CC -!- INDUCTION: Activated by actinomycin-D induced DNA damage.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/ccng2/";
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DR EMBL; U47414; AAC50689.1; -; mRNA.
DR EMBL; L49506; AAC41978.1; -; mRNA.
DR EMBL; AF549495; AAN40704.1; -; Genomic_DNA.
DR EMBL; AK292029; BAF84718.1; -; mRNA.
DR EMBL; AK293899; BAG57286.1; -; mRNA.
DR EMBL; CR542181; CAG46978.1; -; mRNA.
DR EMBL; CR542200; CAG46997.1; -; mRNA.
DR EMBL; BT019503; AAV38310.1; -; mRNA.
DR EMBL; AC008638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC108144; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC112716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05812.1; -; Genomic_DNA.
DR CCDS; CCDS3581.1; -. [Q16589-1]
DR RefSeq; NP_004345.1; NM_004354.2. [Q16589-1]
DR RefSeq; XP_011530700.1; XM_011532398.1. [Q16589-1]
DR RefSeq; XP_011530701.1; XM_011532399.2. [Q16589-1]
DR AlphaFoldDB; Q16589; -.
DR SMR; Q16589; -.
DR BioGRID; 107341; 24.
DR IntAct; Q16589; 2.
DR MINT; Q16589; -.
DR STRING; 9606.ENSP00000315743; -.
DR GlyGen; Q16589; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q16589; -.
DR PhosphoSitePlus; Q16589; -.
DR BioMuta; CCNG2; -.
DR DMDM; 9087132; -.
DR MassIVE; Q16589; -.
DR PaxDb; Q16589; -.
DR PeptideAtlas; Q16589; -.
DR PRIDE; Q16589; -.
DR ProteomicsDB; 4002; -.
DR ProteomicsDB; 60937; -. [Q16589-1]
DR Antibodypedia; 13540; 138 antibodies from 27 providers.
DR DNASU; 901; -.
DR Ensembl; ENST00000316355.10; ENSP00000315743.5; ENSG00000138764.15. [Q16589-1]
DR Ensembl; ENST00000395640.5; ENSP00000379002.1; ENSG00000138764.15. [Q16589-1]
DR Ensembl; ENST00000502280.5; ENSP00000424665.1; ENSG00000138764.15. [Q16589-1]
DR Ensembl; ENST00000509972.1; ENSP00000426476.1; ENSG00000138764.15. [Q16589-2]
DR GeneID; 901; -.
DR KEGG; hsa:901; -.
DR MANE-Select; ENST00000316355.10; ENSP00000315743.5; NM_004354.3; NP_004345.1.
DR UCSC; uc003hkn.5; human. [Q16589-1]
DR CTD; 901; -.
DR DisGeNET; 901; -.
DR GeneCards; CCNG2; -.
DR HGNC; HGNC:1593; CCNG2.
DR HPA; ENSG00000138764; Low tissue specificity.
DR MIM; 603203; gene.
DR neXtProt; NX_Q16589; -.
DR OpenTargets; ENSG00000138764; -.
DR PharmGKB; PA26158; -.
DR VEuPathDB; HostDB:ENSG00000138764; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000156423; -.
DR HOGENOM; CLU_062642_0_1_1; -.
DR InParanoid; Q16589; -.
DR OMA; CEDMMSS; -.
DR PhylomeDB; Q16589; -.
DR TreeFam; TF101007; -.
DR PathwayCommons; Q16589; -.
DR Reactome; R-HSA-9617828; FOXO-mediated transcription of cell cycle genes.
DR SignaLink; Q16589; -.
DR BioGRID-ORCS; 901; 12 hits in 1081 CRISPR screens.
DR ChiTaRS; CCNG2; human.
DR GeneWiki; CCNG2; -.
DR GenomeRNAi; 901; -.
DR Pharos; Q16589; Tbio.
DR PRO; PR:Q16589; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q16589; protein.
DR Bgee; ENSG00000138764; Expressed in amniotic fluid and 204 other tissues.
DR ExpressionAtlas; Q16589; baseline and differential.
DR Genevisible; Q16589; HS.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR028895; CCNG2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF60; PTHR10177:SF60; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cell division; Cyclin; Cytoplasm;
KW Mitosis; Reference proteome.
FT CHAIN 1..344
FT /note="Cyclin-G2"
FT /id="PRO_0000080469"
FT REGION 301..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 304..344
FT /note="SEDSCEDMSCGEESLSSSPPSDQECTFFFNFKVAQTLCFPS -> R (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053893"
FT VARIANT 4
FT /note="L -> V (in dbSNP:rs4150050)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_014333"
FT VARIANT 28
FT /note="E -> G (in dbSNP:rs4150051)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_014334"
FT CONFLICT 127
FT /note="R -> W (in Ref. 5; CAG46997)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 38866 MW; D434E0CE92760301 CRC64;
MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT LCPGLRNAKV
EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC IGVCSFLLAA RIVEEDCNIP
STHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHTIIL CHTSERKEIL
SLDKLEAQLK ACNCRLIFSK AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE
FFYWRELVSK CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD
ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS
