CCNG2_MOUSE
ID CCNG2_MOUSE Reviewed; 344 AA.
AC O08918; O35612;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Cyclin-G2;
GN Name=Ccng2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thymus;
RX PubMed=9139721; DOI=10.1074/jbc.272.19.12650;
RA Horne M.C., Donaldson K.L., Goolsby G.L., Tran D., Mulheisen M., Hell J.W.,
RA Wahl A.F.;
RT "Cyclin G2 is up-regulated during growth inhibition and B cell antigen
RT receptor-mediated cell cycle arrest.";
RL J. Biol. Chem. 272:12650-12661(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=10216255; DOI=10.1016/s0378-1119(99)00057-8;
RA Jensen M.R., Audolfsson T., Keck C.L., Zimonjic D.B., Thorgeirsson S.S.;
RT "Gene structure and chromosomal localization of mouse cyclin G2 (Ccng2).";
RL Gene 230:171-180(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Kimura S.H., Nojima H.;
RT "Genomic structure, chromosomal mapping and p53-independent induction of
RT mouse cyclin G2 gene.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in growth regulation and in negative
CC regulation of cell cycle progression.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Primarily found in the
CC cytoplasm. A minor portion can be detected in some cells in the
CC nucleus.
CC -!- TISSUE SPECIFICITY: Highest levels in intestine. Intermediate levels in
CC spleen, brain and kidney. Low levels in testis, stomach, pancreas,
CC liver, salivary gland and muscle. According to PubMed:9139721 also
CC abundant in thymus.
CC -!- DEVELOPMENTAL STAGE: Expression levels oscillate moderately through the
CC cell cycle.
CC -!- INDUCTION: Activated in B-cells by agents causing growth inhibition or
CC growth arrest.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin G subfamily.
CC {ECO:0000305}.
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DR EMBL; U95826; AAB58693.1; -; mRNA.
DR EMBL; AF005885; AAC28496.1; -; mRNA.
DR EMBL; AF079877; AAC32372.1; -; Genomic_DNA.
DR EMBL; AB035264; BAA87065.1; -; Genomic_DNA.
DR CCDS; CCDS19437.1; -.
DR RefSeq; NP_031661.3; NM_007635.4.
DR AlphaFoldDB; O08918; -.
DR SMR; O08918; -.
DR DIP; DIP-24180N; -.
DR STRING; 10090.ENSMUSP00000031331; -.
DR iPTMnet; O08918; -.
DR PhosphoSitePlus; O08918; -.
DR PaxDb; O08918; -.
DR PRIDE; O08918; -.
DR Antibodypedia; 13540; 138 antibodies from 27 providers.
DR DNASU; 12452; -.
DR Ensembl; ENSMUST00000031331; ENSMUSP00000031331; ENSMUSG00000029385.
DR Ensembl; ENSMUST00000121127; ENSMUSP00000113278; ENSMUSG00000029385.
DR GeneID; 12452; -.
DR KEGG; mmu:12452; -.
DR UCSC; uc008yee.2; mouse.
DR CTD; 901; -.
DR MGI; MGI:1095734; Ccng2.
DR VEuPathDB; HostDB:ENSMUSG00000029385; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000156423; -.
DR HOGENOM; CLU_062642_0_1_1; -.
DR InParanoid; O08918; -.
DR OMA; CEDMMSS; -.
DR OrthoDB; 1015714at2759; -.
DR PhylomeDB; O08918; -.
DR TreeFam; TF101007; -.
DR BioGRID-ORCS; 12452; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ccng2; mouse.
DR PRO; PR:O08918; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; O08918; protein.
DR Bgee; ENSMUSG00000029385; Expressed in medial ganglionic eminence and 258 other tissues.
DR ExpressionAtlas; O08918; baseline and differential.
DR Genevisible; O08918; MM.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IDA:MGI.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR028895; CCNG2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF60; PTHR10177:SF60; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cyclin; Cytoplasm; Mitosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..344
FT /note="Cyclin-G2"
FT /id="PRO_0000080470"
FT REGION 298..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 38848 MW; F6A02698C286D853 CRC64;
MKDLGAKHLA GGEGVQLFGL LNFYLEQEQR YQPREKGLIL MEATPENDNT LCSRLRNAKV
EDLRSLTNFF GSGTETFVLA VNILDRFLAL MKVKPKHLSC IGVCCFLLAA RLAEEEGDVP
PTHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHAIVF CHTSERKEIL
SLDKLEAQLK ACNCRVVFSK ARPSVLALCL LNLEIETIKS VELLEILLLV KKHLKLSDTE
FFYWRELVSK CLAEYSSPRC CKPDLKKLVW IVSRRTAQNL HSSYYSVPEL PTIPEGGCFD
GSESEDSGED MSCGEESLSS SPPSDQECTF FFDFQVAQTL CFPP
