ID   CCNH_BOVIN              Reviewed;         320 AA.
AC   Q3ZBL9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Cyclin-H;
GN   Name=CCNH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating
CC       kinase (CAK) enzymatic complex. CAK activates the cyclin-associated
CC       kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK
CC       complexed to the core-TFIIH basal transcription factor activates RNA
CC       polymerase II by serine phosphorylation of the repetitive C-terminal
CC       domain (CTD) of its large subunit (POLR2A), allowing its escape from
CC       the promoter and elongation of the transcripts. Involved in cell cycle
CC       control and in RNA transcription by RNA polymerase II. Its expression
CC       and activity are constant throughout the cell cycle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates primarily with CDK7 and MAT1 to form the CAK
CC       complex. CAK can further associate with the core-TFIIH to form the
CC       TFIIH basal transcription factor (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC103224; AAI03225.1; -; mRNA.
DR   RefSeq; NP_001073256.1; NM_001079788.2.
DR   AlphaFoldDB; Q3ZBL9; -.
DR   SMR; Q3ZBL9; -.
DR   STRING; 9913.ENSBTAP00000034897; -.
DR   PaxDb; Q3ZBL9; -.
DR   GeneID; 615512; -.
DR   KEGG; bta:615512; -.
DR   CTD; 902; -.
DR   eggNOG; KOG2496; Eukaryota.
DR   InParanoid; Q3ZBL9; -.
DR   OrthoDB; 1469819at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; ISS:UniProtKB.
DR   GO; GO:0070985; C:transcription factor TFIIK complex; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IBA:GO_Central.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR031658; Cyclin_C_2.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR027081; CyclinH/Ccl1.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   Pfam; PF16899; Cyclin_C_2; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   TIGRFAMs; TIGR00569; ccl1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cyclin; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..320
FT                   /note="Cyclin-H"
FT                   /id="PRO_0000282332"
FT   MOD_RES         5
FT                   /note="Phosphoserine; by CDK8"
FT                   /evidence="ECO:0000250|UniProtKB:P51946"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P51946"
FT   MOD_RES         304
FT                   /note="Phosphoserine; by CDK8"
FT                   /evidence="ECO:0000250|UniProtKB:P51946"
SQ   SEQUENCE   320 AA;  37028 MW;  A46D122811F65AFF CRC64;
     MYHNSSQKRH WTFASEEQLA RLRADANRKF KCKAVANGKV LPNDPVFLEP HEEITLCKYY
     EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV
     SSPQFVGNLR ESPLGQEKTL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPL
     LENPEILRKT ADDFLNRVAL TDAHLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE
     NRTSLSQLLD IMKSMRNLVK KYEPPRPEEV AALKQKLERC HSAELALNVV TKKRKGYEDD
     DYVSKKSKHE EVCSPKGSFM