ID   CCNH_XENLA              Reviewed;         323 AA.
AC   P51947;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Cyclin-H;
DE   AltName: Full=MO15-associated protein;
DE   AltName: Full=p36;
GN   Name=ccnh;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RA   Martinez A.-M.;
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Oocyte;
RX   PubMed=7957080; DOI=10.1002/j.1460-2075.1994.tb06845.x;
RA   Labbe J.-C., Martinez A.-M., Fesquet D., Capony J.-P., Darbon J.-M.,
RA   Derancourt J., Devault A., Morin N., Cavadore J.-C., Doree M.;
RT   "p40MO15 associates with a p36 subunit and requires both nuclear
RT   translocation and Thr176 phosphorylation to generate cdk-activating kinase
RT   activity in Xenopus oocytes.";
RL   EMBO J. 13:5155-5164(1994).
CC   -!- FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating
CC       kinase (CAK) enzymatic complex. CAK activates the cyclin-associated
CC       kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK
CC       complexed to the core-TFIIH basal transcription factor activates RNA
CC       polymerase II by serine phosphorylation of the repetitive C-terminal
CC       domain (CTD) of its large subunit (POLR2A), allowing its escape from
CC       the promoter and elongation of the transcripts. Involved in cell cycle
CC       control and in RNA transcription by RNA polymerase II. Its expression
CC       and activity are constant throughout the cell cycle (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates primarily with CDK7 and MAT1 to form the CAK
CC       complex. CAK can further associate with the core-TFIIH to form the
CC       TFIIH basal transcription factor.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U20505; AAA62236.1; -; mRNA.
DR   RefSeq; NP_001081052.1; NM_001087583.1.
DR   AlphaFoldDB; P51947; -.
DR   SMR; P51947; -.
DR   MaxQB; P51947; -.
DR   PRIDE; P51947; -.
DR   DNASU; 394356; -.
DR   GeneID; 394356; -.
DR   KEGG; xla:394356; -.
DR   CTD; 394356; -.
DR   Xenbase; XB-GENE-922574; ccnh.L.
DR   OrthoDB; 1469819at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 394356; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0070985; C:transcription factor TFIIK complex; IEA:InterPro.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR031658; Cyclin_C_2.
DR   InterPro; IPR006671; Cyclin_N.
DR   InterPro; IPR027081; CyclinH/Ccl1.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   Pfam; PF16899; Cyclin_C_2; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   TIGRFAMs; TIGR00569; ccl1; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cyclin; Direct protein sequencing; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..323
FT                   /note="Cyclin-H"
FT                   /id="PRO_0000080474"
FT   REGION          296..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..313
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        266
FT                   /note="R -> Y (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   323 AA;  37600 MW;  14BCDCA000843DC8 CRC64;
     MYHNSTQKKH WTFLSEDEPL RRRIQANVRY RARIRATEKP RLSEIFSLEP HEELAICKYY
     EKRLLDFCNA FKPTMPKSVL GTACMYFKRF YLNNSVMEHH PRIIMLTCVF LACKVDEFNV
     SSIQFVGNLG ENPLGQEKIL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDVKTRYPM
     LENPEVLRKS ADEFLNRVAL TDACLLFAPS VIALTAILST ASRAGLNMES YLTECLSLKD
     NQETMSHLLD GMRRLKILVS KYEPARPEEV AALKKRLDHC HSTEVTLSVH GRKRKGYEDD
     GYISKKPKTE EDEWTDEDFG DSL