CCNI2_HUMAN
ID CCNI2_HUMAN Reviewed; 369 AA.
AC Q6ZMN8; B2RNE2; B7ZMB7; B7ZMB8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cyclin-I2;
GN Name=CCNI2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZMN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZMN8-2; Sequence=VSP_057180;
CC Name=3;
CC IsoId=Q6ZMN8-3; Sequence=VSP_057179;
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR EMBL; AK131553; BAD18687.1; -; mRNA.
DR EMBL; BC132837; AAI32838.1; -; mRNA.
DR EMBL; BC136836; AAI36837.1; -; mRNA.
DR EMBL; BC144416; AAI44417.1; -; mRNA.
DR EMBL; BC144417; AAI44418.1; -; mRNA.
DR CCDS; CCDS34236.1; -. [Q6ZMN8-1]
DR CCDS; CCDS75297.1; -. [Q6ZMN8-2]
DR RefSeq; NP_001034869.1; NM_001039780.3. [Q6ZMN8-1]
DR RefSeq; NP_001274181.1; NM_001287252.1. [Q6ZMN8-2]
DR RefSeq; NP_001274182.1; NM_001287253.1. [Q6ZMN8-3]
DR AlphaFoldDB; Q6ZMN8; -.
DR SMR; Q6ZMN8; -.
DR BioGRID; 570168; 69.
DR IntAct; Q6ZMN8; 3.
DR STRING; 9606.ENSP00000478257; -.
DR iPTMnet; Q6ZMN8; -.
DR PhosphoSitePlus; Q6ZMN8; -.
DR BioMuta; CCNI2; -.
DR DMDM; 74749548; -.
DR MassIVE; Q6ZMN8; -.
DR PaxDb; Q6ZMN8; -.
DR PeptideAtlas; Q6ZMN8; -.
DR PRIDE; Q6ZMN8; -.
DR ProteomicsDB; 67895; -. [Q6ZMN8-1]
DR Antibodypedia; 45187; 92 antibodies from 23 providers.
DR DNASU; 645121; -.
DR Ensembl; ENST00000378731.6; ENSP00000368005.1; ENSG00000205089.8. [Q6ZMN8-1]
DR Ensembl; ENST00000614847.1; ENSP00000478257.1; ENSG00000205089.8. [Q6ZMN8-2]
DR GeneID; 645121; -.
DR KEGG; hsa:645121; -.
DR MANE-Select; ENST00000378731.6; ENSP00000368005.1; NM_001039780.4; NP_001034869.1.
DR UCSC; uc003kxq.3; human. [Q6ZMN8-1]
DR CTD; 645121; -.
DR GeneCards; CCNI2; -.
DR HGNC; HGNC:33869; CCNI2.
DR HPA; ENSG00000205089; Tissue enhanced (brain, intestine).
DR neXtProt; NX_Q6ZMN8; -.
DR OpenTargets; ENSG00000205089; -.
DR PharmGKB; PA162381968; -.
DR VEuPathDB; HostDB:ENSG00000205089; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000162679; -.
DR HOGENOM; CLU_065929_0_0_1; -.
DR InParanoid; Q6ZMN8; -.
DR OMA; NIKNHGL; -.
DR OrthoDB; 1015714at2759; -.
DR PhylomeDB; Q6ZMN8; -.
DR TreeFam; TF101007; -.
DR PathwayCommons; Q6ZMN8; -.
DR SignaLink; Q6ZMN8; -.
DR BioGRID-ORCS; 645121; 8 hits in 1064 CRISPR screens.
DR GenomeRNAi; 645121; -.
DR Pharos; Q6ZMN8; Tdark.
DR PRO; PR:Q6ZMN8; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q6ZMN8; protein.
DR Bgee; ENSG00000205089; Expressed in primary visual cortex and 93 other tissues.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR028861; CCNI2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF57; PTHR10177:SF57; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cyclin; Reference proteome.
FT CHAIN 1..369
FT /note="Cyclin-I2"
FT /id="PRO_0000335821"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 143
FT /note="Q -> QQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_057179"
FT VAR_SEQ 258
FT /note="I -> IEKYGVFCSNIKNHGLQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_057180"
FT VARIANT 91
FT /note="A -> P (in dbSNP:rs803056)"
FT /id="VAR_043471"
SQ SEQUENCE 369 AA; 40622 MW; 68B887A9C0044708 CRC64;
MASGAQLPPQ PSSSEVSAVQ SPGGRPGAGL EETALGVPLP PSPGEAPLPR SNRSRCPGTR
QPGAASLHAA SAAVPVRPRR GTAPAGKTAD AVPAAAPEQA PRPAPQSRKP RNLEGDLDER
RLLCHLQLAQ DREARLWRGG KPQDEICDAF EEVVLWLLRL QNTFYFSQST FNLALTIFGR
LLISVKVKEK YLHCATITSL RLAAKVNEEE EFIPQVKDFT KHYGSDYSPN ELLRMELAIL
DRLHWDLYIG TPLDFLTIFH ALVVLSWPHV LELLPQRNPS LHVASLTRQL QHCMAGHQLL
QFKGSTLALV IITLELERLM PGWCAPISDL LKKAQVGDMQ YSCCKELVMQ QLRSLQSSSC
TDNFVSPAN
