CCNI_HUMAN
ID CCNI_HUMAN Reviewed; 377 AA.
AC Q14094; B2R6M0; B7Z6X4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Cyclin-I {ECO:0000305};
GN Name=CCNI {ECO:0000312|HGNC:HGNC:1595};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Forebrain cortex;
RX PubMed=7493655; DOI=10.1006/excr.1995.1406;
RA Nakamura T., Sanokawa R., Sasaki Y.F., Ayusawa D., Oishi M., Mori N.;
RT "Cyclin I: a new cyclin encoded by a gene isolated from human brain.";
RL Exp. Cell Res. 221:534-542(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Chen J.H., Luo W.Q., Zhou Y., Zhou H.J., Huang X.W., Yuan J.G., Qiang B.Q.;
RT "Isolating a new cDNA coding for human cyclin protein.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-207.
RG NIEHS SNPs program;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-178 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=9705831; DOI=10.1006/bbrc.1998.9052;
RA Zhu X., Naz R.K.;
RT "Expression of a novel isoform of cyclin I in human testis.";
RL Biochem. Biophys. Res. Commun. 249:56-60(1998).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=28860486; DOI=10.1038/s41598-017-10770-8;
RA Gasa L., Sanchez-Botet A., Quandt E., Hernandez-Ortega S., Jimenez J.,
RA Carrasco-Garcia M.A., Simonetti S., Kron S.J., Ribeiro M.P., Nadal E.,
RA Villanueva A., Clotet J.;
RT "A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic
RT driver in lung cancer.";
RL Sci. Rep. 7:10228-10228(2017).
CC -!- INTERACTION:
CC Q14094; Q00526: CDK3; NbExp=3; IntAct=EBI-1104653, EBI-1245761;
CC Q14094; Q00535: CDK5; NbExp=4; IntAct=EBI-1104653, EBI-1041567;
CC Q14094; Q00534: CDK6; NbExp=3; IntAct=EBI-1104653, EBI-295663;
CC Q14094; Q96E35: ZMYND19; NbExp=3; IntAct=EBI-1104653, EBI-746595;
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:28860486}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14094-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14094-2; Sequence=VSP_056682;
CC -!- TISSUE SPECIFICITY: Highest levels in adult heart, brain and skeletal
CC muscle. Lower levels in adult placenta, lung, kidney and pancreas. Also
CC high levels in fetal brain and lower levels in fetal lung, liver and
CC kidney. Also abundant in testis and thyroid.
CC {ECO:0000269|PubMed:7493655}.
CC -!- DEVELOPMENTAL STAGE: Expression is independent of the cell cycle in
CC lung fibroblasts. {ECO:0000269|PubMed:7493655}.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/ccni/";
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DR EMBL; D50310; BAA08849.1; -; mRNA.
DR EMBL; AF135162; AAF43786.1; -; mRNA.
DR EMBL; BT020019; AAV38822.1; -; mRNA.
DR EMBL; AY207372; AAO13492.1; -; Genomic_DNA.
DR EMBL; AK301111; BAH13410.1; -; mRNA.
DR EMBL; AK312632; BAG35517.1; -; mRNA.
DR EMBL; AC104771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC111196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05808.1; -; Genomic_DNA.
DR EMBL; BC000420; AAH00420.1; -; mRNA.
DR EMBL; BC004975; AAH04975.1; -; mRNA.
DR CCDS; CCDS3580.1; -. [Q14094-1]
DR PIR; JE0264; JE0264.
DR RefSeq; NP_001335061.1; NM_001348132.1. [Q14094-1]
DR RefSeq; NP_001335062.1; NM_001348133.1. [Q14094-1]
DR RefSeq; NP_001335063.1; NM_001348134.1. [Q14094-2]
DR RefSeq; NP_006826.1; NM_006835.2. [Q14094-1]
DR AlphaFoldDB; Q14094; -.
DR SMR; Q14094; -.
DR BioGRID; 116179; 14.
DR IntAct; Q14094; 11.
DR MINT; Q14094; -.
DR STRING; 9606.ENSP00000237654; -.
DR iPTMnet; Q14094; -.
DR PhosphoSitePlus; Q14094; -.
DR BioMuta; CCNI; -.
DR DMDM; 9296954; -.
DR EPD; Q14094; -.
DR MassIVE; Q14094; -.
DR MaxQB; Q14094; -.
DR PaxDb; Q14094; -.
DR PeptideAtlas; Q14094; -.
DR PRIDE; Q14094; -.
DR ProteomicsDB; 59809; -. [Q14094-1]
DR ProteomicsDB; 6814; -.
DR Antibodypedia; 4127; 174 antibodies from 26 providers.
DR DNASU; 10983; -.
DR Ensembl; ENST00000237654.9; ENSP00000237654.4; ENSG00000118816.11. [Q14094-1]
DR GeneID; 10983; -.
DR KEGG; hsa:10983; -.
DR MANE-Select; ENST00000237654.9; ENSP00000237654.4; NM_006835.3; NP_006826.1.
DR UCSC; uc003hkm.5; human. [Q14094-1]
DR CTD; 10983; -.
DR DisGeNET; 10983; -.
DR GeneCards; CCNI; -.
DR HGNC; HGNC:1595; CCNI.
DR HPA; ENSG00000118816; Low tissue specificity.
DR MIM; 618783; gene.
DR neXtProt; NX_Q14094; -.
DR OpenTargets; ENSG00000118816; -.
DR PharmGKB; PA26160; -.
DR VEuPathDB; HostDB:ENSG00000118816; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000154827; -.
DR HOGENOM; CLU_062642_1_0_1; -.
DR InParanoid; Q14094; -.
DR OMA; ADHTLMQ; -.
DR OrthoDB; 297055at2759; -.
DR PhylomeDB; Q14094; -.
DR TreeFam; TF101007; -.
DR PathwayCommons; Q14094; -.
DR SignaLink; Q14094; -.
DR BioGRID-ORCS; 10983; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; CCNI; human.
DR GeneWiki; CCNI_(gene); -.
DR GenomeRNAi; 10983; -.
DR Pharos; Q14094; Tbio.
DR PRO; PR:Q14094; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q14094; protein.
DR Bgee; ENSG00000118816; Expressed in paraflocculus and 215 other tissues.
DR ExpressionAtlas; Q14094; baseline and differential.
DR Genevisible; Q14094; HS.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; NAS:UniProtKB.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR028856; Cyclin_I.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF187; PTHR10177:SF187; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cyclin; Membrane; Nucleus; Reference proteome.
FT CHAIN 1..377
FT /note="Cyclin-I"
FT /id="PRO_0000080476"
FT REGION 357..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..38
FT /note="MKFPGPLENQRLSFLLEKAITREAQMWKVNVRKMPSNQ -> MTPRHHCEAY
FT SSAGEEEEEEEEEK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056682"
FT VARIANT 207
FT /note="V -> I (in dbSNP:rs4252903)"
FT /evidence="ECO:0000269|Ref.4"
FT /id="VAR_016312"
FT CONFLICT 9
FT /note="N -> D (in Ref. 9; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="Q -> R (in Ref. 9; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="R -> G (in Ref. 9; no nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 377 AA; 42557 MW; 2DE84EFA74698F6C CRC64;
MKFPGPLENQ RLSFLLEKAI TREAQMWKVN VRKMPSNQNV SPSQRDEVIQ WLAKLKYQFN
LYPETFALAS SLLDRFLATV KAHPKYLSCI AISCFFLAAK TVEEDERIPV LKVLARDSFC
GCSSSEILRM ERIILDKLNW DLHTATPLDF LHIFHAIAVS TRPQLLFSLP KLSPSQHLAV
LTKQLLHCMA CNQLLQFRGS MLALAMVSLE MEKLIPDWLS LTIELLQKAQ MDSSQLIHCR
ELVAHHLSTL QSSLPLNSVY VYRPLKHTLV TCDKGVFRLH PSSVPGPDFS KDNSKPEVPV
RGTAAFYHHL PAASGCKQTS TKRKVEEMEV DDFYDGIKRL YNEDNVSENV GSVCGTDLSR
QEGHASPCPP LQPVSVM
