ID   CCNI_MOUSE              Reviewed;         377 AA.
AC   Q9Z2V9; G3X985;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 4.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Cyclin-I;
GN   Name=Ccni;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=10072591; DOI=10.1159/000015192;
RA   Jensen M.R., Audolfsson T., Keck C.L., Zimonjic D.B., Thorgeirsson S.S.;
RT   "Assignment of the cyclin I gene (Ccni) to mouse chromosome 5E3.3-F1. 3 by
RT   in situ hybridization.";
RL   Cytogenet. Cell Genet. 83:242-243(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=11054536; DOI=10.1016/s0378-1119(00)00361-9;
RA   Jensen M.R., Audolfsson T., Factor V.M., Thorgeirsson S.S.;
RT   "In vivo expression and genomic organization of the mouse cyclin I gene
RT   (Ccni).";
RL   Gene 256:59-67(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR   EMBL; AC134827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466617; EDL05230.1; -; Genomic_DNA.
DR   EMBL; CH466617; EDL05231.1; -; Genomic_DNA.
DR   EMBL; AF005886; AAD01253.2; -; mRNA.
DR   EMBL; AF228740; AAF43391.1; -; Genomic_DNA.
DR   EMBL; AF228739; AAF43391.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS19436.1; -.
DR   RefSeq; NP_059063.2; NM_017367.3.
DR   RefSeq; XP_006534799.1; XM_006534736.3.
DR   AlphaFoldDB; Q9Z2V9; -.
DR   SMR; Q9Z2V9; -.
DR   STRING; 10090.ENSMUSP00000050189; -.
DR   iPTMnet; Q9Z2V9; -.
DR   PhosphoSitePlus; Q9Z2V9; -.
DR   PaxDb; Q9Z2V9; -.
DR   PRIDE; Q9Z2V9; -.
DR   ProteomicsDB; 265617; -.
DR   Antibodypedia; 4127; 174 antibodies from 26 providers.
DR   DNASU; 12453; -.
DR   Ensembl; ENSMUST00000058550; ENSMUSP00000050189; ENSMUSG00000063015.
DR   GeneID; 12453; -.
DR   KEGG; mmu:12453; -.
DR   UCSC; uc008yed.2; mouse.
DR   CTD; 10983; -.
DR   MGI; MGI:1341077; Ccni.
DR   VEuPathDB; HostDB:ENSMUSG00000063015; -.
DR   eggNOG; KOG0653; Eukaryota.
DR   GeneTree; ENSGT00940000154827; -.
DR   HOGENOM; CLU_062642_1_0_1; -.
DR   InParanoid; Q9Z2V9; -.
DR   OMA; ADHTLMQ; -.
DR   OrthoDB; 1015714at2759; -.
DR   PhylomeDB; Q9Z2V9; -.
DR   TreeFam; TF101007; -.
DR   BioGRID-ORCS; 12453; 4 hits in 72 CRISPR screens.
DR   ChiTaRS; Ccni; mouse.
DR   PRO; PR:Q9Z2V9; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9Z2V9; protein.
DR   Bgee; ENSMUSG00000063015; Expressed in cortical plate and 65 other tissues.
DR   ExpressionAtlas; Q9Z2V9; baseline and differential.
DR   Genevisible; Q9Z2V9; MM.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; ISS:MGI.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR   GO; GO:0051726; P:regulation of cell cycle; TAS:MGI.
DR   GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR039361; Cyclin.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR028856; Cyclin_I.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10177; PTHR10177; 1.
DR   PANTHER; PTHR10177:SF187; PTHR10177:SF187; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   2: Evidence at transcript level;
KW   Cyclin; Reference proteome.
FT   CHAIN           1..377
FT                   /note="Cyclin-I"
FT                   /id="PRO_0000080477"
FT   REGION          356..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        161
FT                   /note="A -> T (in Ref. 2; AAD01253/AAF43391)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   377 AA;  42197 MW;  828A6E59846ED5BE CRC64;
     MKFPGPLENQ RLSSLLERAI SREAQMWKVN VPKIPTNQNV SPSQRDEVIQ WLAKLKYQFN
     LYPETFALAS SLLDRFLATV KAHPKYLNCI AISCFFLAAK TVEEDEKIPV LKVLARDSFC
     GCSSSEILRM ERIILDKLNW DLHTATPLDF LHIFHAIAVS ARPQLLFSLP KLSPSQHLAV
     LTKQLLHCMA CNQLLQFKGS MLALAMVSLE MEKLIPDWLP LTIELLQKAQ MDSSQLIHCR
     ELVAYHLSAL QSALPLNSVY VYRPLKHTLV TCDKGAFKLH PSSVSGPDFS KDNSKPEVPV
     RGPAAFHLHL PAASGCKQTS AKRKVEEMEV DDFYDGIKRL YNEDNGPENV GSVCGTDLSR
     QEGHASPCPP LQPVSVM