CCNJL_HUMAN
ID CCNJL_HUMAN Reviewed; 435 AA.
AC Q8IV13; Q6ZN43; Q9H7W8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Cyclin-J-like protein;
GN Name=CCNJL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 248-435 (ISOFORM 1).
RC TISSUE=Brain, and Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8IV13; Q16512: PKN1; NbExp=3; IntAct=EBI-21668062, EBI-602382;
CC Q8IV13; P31930: UQCRC1; NbExp=3; IntAct=EBI-21668062, EBI-1052596;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IV13-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IV13-2; Sequence=VSP_029130, VSP_029131, VSP_029132;
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin J subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH13353.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB14856.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK024228; BAB14856.1; ALT_INIT; mRNA.
DR EMBL; AK131381; BAD18532.1; -; mRNA.
DR EMBL; BC013353; AAH13353.1; ALT_INIT; mRNA.
DR EMBL; BC035871; AAH35871.3; -; mRNA.
DR CCDS; CCDS4350.2; -. [Q8IV13-1]
DR RefSeq; NP_001295102.1; NM_001308173.1.
DR RefSeq; NP_078841.3; NM_024565.6. [Q8IV13-1]
DR RefSeq; XP_016865338.1; XM_017009849.1.
DR AlphaFoldDB; Q8IV13; -.
DR SMR; Q8IV13; -.
DR BioGRID; 122749; 43.
DR IntAct; Q8IV13; 24.
DR STRING; 9606.ENSP00000377547; -.
DR iPTMnet; Q8IV13; -.
DR PhosphoSitePlus; Q8IV13; -.
DR BioMuta; CCNJL; -.
DR DMDM; 121946266; -.
DR MassIVE; Q8IV13; -.
DR PaxDb; Q8IV13; -.
DR PeptideAtlas; Q8IV13; -.
DR PRIDE; Q8IV13; -.
DR ProteomicsDB; 70641; -. [Q8IV13-1]
DR ProteomicsDB; 70642; -. [Q8IV13-2]
DR Antibodypedia; 45857; 118 antibodies from 19 providers.
DR DNASU; 79616; -.
DR Ensembl; ENST00000393977.7; ENSP00000377547.3; ENSG00000135083.17. [Q8IV13-1]
DR GeneID; 79616; -.
DR KEGG; hsa:79616; -.
DR UCSC; uc003lyb.2; human. [Q8IV13-1]
DR CTD; 79616; -.
DR GeneCards; CCNJL; -.
DR HGNC; HGNC:25876; CCNJL.
DR HPA; ENSG00000135083; Tissue enhanced (brain).
DR neXtProt; NX_Q8IV13; -.
DR OpenTargets; ENSG00000135083; -.
DR PharmGKB; PA144596449; -.
DR VEuPathDB; HostDB:ENSG00000135083; -.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00940000159349; -.
DR InParanoid; Q8IV13; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; Q8IV13; -.
DR TreeFam; TF101009; -.
DR PathwayCommons; Q8IV13; -.
DR SignaLink; Q8IV13; -.
DR BioGRID-ORCS; 79616; 10 hits in 1073 CRISPR screens.
DR ChiTaRS; CCNJL; human.
DR GenomeRNAi; 79616; -.
DR Pharos; Q8IV13; Tdark.
DR PRO; PR:Q8IV13; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8IV13; protein.
DR Bgee; ENSG00000135083; Expressed in blood and 102 other tissues.
DR ExpressionAtlas; Q8IV13; baseline and differential.
DR Genevisible; Q8IV13; HS.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cyclin; Reference proteome.
FT CHAIN 1..435
FT /note="Cyclin-J-like protein"
FT /id="PRO_0000309319"
FT DOMAIN 14..191
FT /note="Cyclin N-terminal"
FT REGION 120..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..23
FT /note="MMDEPWWEGRVASDVHCTLREKE -> MRHTSKRKPQYYEAEMVLKYYKHLE
FT EGSVSLCCPGWSAVAQSRLTAASTFGAQVILLFQLSEQLRLQE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029130"
FT VAR_SEQ 94..121
FT /note="NGVSLLSPRLKCSGMISAHCNLHLPGSS -> SRNKGSGSPVPTRSAQQCRQ
FT TWARGSPW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029131"
FT VAR_SEQ 122..435
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029132"
FT VARIANT 234
FT /note="H -> Y (in dbSNP:rs13362036)"
FT /id="VAR_053053"
SQ SEQUENCE 435 AA; 48406 MW; 1AC6A15E632C6680 CRC64;
MMDEPWWEGR VASDVHCTLR EKELKLPTFR AHSPLLKSRR FFVDILTLLS SHCQLCPAAR
HLAVYLLDHF MDRYNVTTSK QLYTVAVSCL LLANGVSLLS PRLKCSGMIS AHCNLHLPGS
SNSPASAPHP PPTPPQVAET TGKFEDREDH VPKLEQINST RILSSQNFTL TKKELLSTEL
LLLEAFSWNL CLPTPAHFLD YYLLASVSQK DHHCHTWPTT CPRKTKECLK EYAHYFLEVT
LQDHIFYKFQ PSVVAAACVG ASRICLQLSP YWTRDLQRIS SYSLEHLSTC IEILLVVYDN
VLKDAVAVKS QALAMVPGTP PTPTQVLFQP PAYPALGQPA TTLAQFQTPV QDLCLAYRDS
LQAHRSGSLL SGSTGSSLHT PYQPLQPLDM CPVPVPASLS MHMAIAAEPR HCLATTYGSS
YFSGSHMFPT GCFDR
