CCNJ_HUMAN
ID CCNJ_HUMAN Reviewed; 372 AA.
AC Q5T5M9; B7Z4E7; Q86XL1; Q9NV69;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Cyclin-J;
GN Name=CCNJ;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 127-372 (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5T5M9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T5M9-2; Sequence=VSP_029128;
CC Name=3;
CC IsoId=Q5T5M9-3; Sequence=VSP_041163;
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91887.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK001757; BAA91887.1; ALT_INIT; mRNA.
DR EMBL; AK297264; BAH12533.1; -; mRNA.
DR EMBL; AL356155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043175; AAH43175.1; -; mRNA.
DR CCDS; CCDS44462.1; -. [Q5T5M9-3]
DR CCDS; CCDS44463.1; -. [Q5T5M9-2]
DR CCDS; CCDS7445.1; -. [Q5T5M9-1]
DR RefSeq; NP_001127847.1; NM_001134375.1. [Q5T5M9-3]
DR RefSeq; NP_001127848.1; NM_001134376.1. [Q5T5M9-2]
DR RefSeq; NP_061957.2; NM_019084.4. [Q5T5M9-1]
DR RefSeq; XP_011538187.1; XM_011539885.2. [Q5T5M9-3]
DR AlphaFoldDB; Q5T5M9; -.
DR SMR; Q5T5M9; -.
DR BioGRID; 120077; 12.
DR IntAct; Q5T5M9; 4.
DR STRING; 9606.ENSP00000435373; -.
DR iPTMnet; Q5T5M9; -.
DR PhosphoSitePlus; Q5T5M9; -.
DR BioMuta; CCNJ; -.
DR DMDM; 160380581; -.
DR MassIVE; Q5T5M9; -.
DR PaxDb; Q5T5M9; -.
DR PeptideAtlas; Q5T5M9; -.
DR PRIDE; Q5T5M9; -.
DR ProteomicsDB; 64530; -. [Q5T5M9-1]
DR ProteomicsDB; 64531; -. [Q5T5M9-2]
DR ProteomicsDB; 64532; -. [Q5T5M9-3]
DR Antibodypedia; 16889; 137 antibodies from 21 providers.
DR DNASU; 54619; -.
DR Ensembl; ENST00000265992.9; ENSP00000265992.5; ENSG00000107443.16. [Q5T5M9-1]
DR Ensembl; ENST00000403870.7; ENSP00000384498.2; ENSG00000107443.16. [Q5T5M9-2]
DR Ensembl; ENST00000465148.3; ENSP00000435373.2; ENSG00000107443.16. [Q5T5M9-3]
DR GeneID; 54619; -.
DR KEGG; hsa:54619; -.
DR MANE-Select; ENST00000465148.3; ENSP00000435373.2; NM_001134375.2; NP_001127847.1. [Q5T5M9-3]
DR UCSC; uc001klm.4; human. [Q5T5M9-1]
DR CTD; 54619; -.
DR DisGeNET; 54619; -.
DR GeneCards; CCNJ; -.
DR HGNC; HGNC:23434; CCNJ.
DR HPA; ENSG00000107443; Low tissue specificity.
DR neXtProt; NX_Q5T5M9; -.
DR OpenTargets; ENSG00000107443; -.
DR PharmGKB; PA134911603; -.
DR VEuPathDB; HostDB:ENSG00000107443; -.
DR eggNOG; ENOG502QWGF; Eukaryota.
DR GeneTree; ENSGT00940000156981; -.
DR HOGENOM; CLU_063883_0_1_1; -.
DR InParanoid; Q5T5M9; -.
DR OMA; QNCQQIV; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; Q5T5M9; -.
DR TreeFam; TF101009; -.
DR PathwayCommons; Q5T5M9; -.
DR SignaLink; Q5T5M9; -.
DR BioGRID-ORCS; 54619; 16 hits in 1080 CRISPR screens.
DR GenomeRNAi; 54619; -.
DR Pharos; Q5T5M9; Tbio.
DR PRO; PR:Q5T5M9; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5T5M9; protein.
DR Bgee; ENSG00000107443; Expressed in secondary oocyte and 181 other tissues.
DR Genevisible; Q5T5M9; HS.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR028859; Cyclin-J.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF62; PTHR10177:SF62; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cyclin; Reference proteome.
FT CHAIN 1..372
FT /note="Cyclin-J"
FT /id="PRO_0000309316"
FT DOMAIN 15..143
FT /note="Cyclin N-terminal"
FT VAR_SEQ 193
FT /note="Q -> QDYAFLNYAPSL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041163"
FT VAR_SEQ 194
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029128"
SQ SEQUENCE 372 AA; 42581 MW; 5CCADA91E11CF5D7 CRC64;
MELEGQWWRG QLAADIHQAL RYKELKLPSY KGQSPQLSLR RYFADLIAIV SNRFTLCPSA
RHLAVYLLDL FMDRYDISIQ QLHLVALSCL LLASKFEEKE DSVPKLEQLN SLGCMTNMNL
VLTKQNLLHM ELLLLETFQW NLCLPTAAHF IEYYLSEAVH ETDLHDGWPM ICLEKTKLYM
AKYADYFLEV SLQVAAACVA SSRIILRLSP TWPTRLHRLT AYSWDFLVQC IERLLIAHDN
DVKEANKQRG QAGPQSAQLS VFQTASQPSR PVHFQQPQYL HQTHQTSLQY RHPTSEQPSC
QQIVSTTHTS SYTLQTCPAG FQTSVQGLGH MQTGVGMSLA IPVEVKPCLS VSYNRSYQIN
EHYPCITPCF ER
