CCNJ_MOUSE
ID CCNJ_MOUSE Reviewed; 379 AA.
AC Q3TZI6; Q1ED41; Q8BIY5;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cyclin-J;
GN Name=Ccnj;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic lung, and Erythroblast;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TZI6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TZI6-2; Sequence=VSP_029129;
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin J subfamily.
CC {ECO:0000305}.
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DR EMBL; AK052506; BAC35020.1; -; mRNA.
DR EMBL; AK157841; BAE34222.1; -; mRNA.
DR EMBL; BC117559; AAI17560.1; -; mRNA.
DR EMBL; BC120921; AAI20922.1; -; mRNA.
DR EMBL; BC120922; AAI20923.1; -; mRNA.
DR CCDS; CCDS29806.1; -. [Q3TZI6-1]
DR RefSeq; NP_766427.1; NM_172839.4. [Q3TZI6-1]
DR RefSeq; XP_011245550.1; XM_011247248.1. [Q3TZI6-2]
DR RefSeq; XP_017173689.1; XM_017318200.1. [Q3TZI6-1]
DR AlphaFoldDB; Q3TZI6; -.
DR SMR; Q3TZI6; -.
DR STRING; 10090.ENSMUSP00000025983; -.
DR iPTMnet; Q3TZI6; -.
DR PhosphoSitePlus; Q3TZI6; -.
DR PaxDb; Q3TZI6; -.
DR PRIDE; Q3TZI6; -.
DR Antibodypedia; 16889; 137 antibodies from 21 providers.
DR DNASU; 240665; -.
DR Ensembl; ENSMUST00000025983; ENSMUSP00000025983; ENSMUSG00000025010. [Q3TZI6-1]
DR Ensembl; ENSMUST00000119316; ENSMUSP00000112643; ENSMUSG00000025010. [Q3TZI6-1]
DR GeneID; 240665; -.
DR KEGG; mmu:240665; -.
DR UCSC; uc008hlh.2; mouse. [Q3TZI6-2]
DR UCSC; uc012blp.1; mouse. [Q3TZI6-1]
DR CTD; 54619; -.
DR MGI; MGI:2443297; Ccnj.
DR VEuPathDB; HostDB:ENSMUSG00000025010; -.
DR eggNOG; ENOG502QWGF; Eukaryota.
DR GeneTree; ENSGT00940000156981; -.
DR HOGENOM; CLU_063883_0_1_1; -.
DR InParanoid; Q3TZI6; -.
DR OMA; QNCQQIV; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; Q3TZI6; -.
DR TreeFam; TF101009; -.
DR BioGRID-ORCS; 240665; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q3TZI6; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q3TZI6; protein.
DR Bgee; ENSMUSG00000025010; Expressed in pharyngeal arch 2 and 231 other tissues.
DR Genevisible; Q3TZI6; MM.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR028859; Cyclin-J.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF62; PTHR10177:SF62; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cyclin; Reference proteome.
FT CHAIN 1..379
FT /note="Cyclin-J"
FT /id="PRO_0000309317"
FT DOMAIN 15..143
FT /note="Cyclin N-terminal"
FT VAR_SEQ 194..205
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029129"
FT CONFLICT 117
FT /note="N -> Y (in Ref. 1; BAE34222)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 379 AA; 43488 MW; 3C7FF2FC30EA1959 CRC64;
MELEGQWWRG QLAADIHQAL RYKELKLPSY KGQSPQLNLR RYFADLIAIV SNRFTLCPPA
RHLAVYLLDL FMDRYDISIQ QLHLVALSCL LLASKFEEKE DSVPKLEQLN SLGCMTNMNL
VLTKQTLLHM ELLLLETFQW NLCLPTAAHF IEYYLSEAVH ETDLHDGWPM VCLEKTKLYM
AKYADYFLEV SLQDYAFLNY APSLVAAACV ASSRIILRLS PTWPTRLHRL TAYSWDFLVQ
CIERLLLAHD NDVKEANKQR GQSAPQSTQL TVFQTAQPSR PVHFQQPQYL HQSSLQYRHP
VSEQPSRQQI VSTTHTSSYT LQTCPAGFQT SVQGLGHMQT GVGMSLAIPV EVKPCLSVSY
NRSYQINEHF PCITPCFER
