CCNK_DANRE
ID CCNK_DANRE Reviewed; 425 AA.
AC F1QMB9; A1A5X9;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2018, sequence version 3.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Cyclin-K;
GN Name=ccnk; ORFNames=si:dkey-60a16.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAI28854.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=30122539; DOI=10.1016/j.ajhg.2018.07.019;
RA Fan Y., Yin W., Hu B., Kline A.D., Zhang V.W., Liang D., Sun Y., Wang L.,
RA Tang S., Powis Z., Li L., Yan H., Shi Z., Yang X., Chen Y., Wang J.,
RA Jiang Y., Tan H., Gu X., Wu L., Yu Y.;
RT "De novo mutations of CCNK cause a syndromic neurodevelopmental disorder
RT with distinctive facial dysmorphism.";
RL Am. J. Hum. Genet. 103:448-455(2018).
CC -!- FUNCTION: Regulatory subunit of cyclin-dependent kinases that mediates
CC activation of target kinases. Plays a role in transcriptional
CC regulation via its role in regulating the phosphorylation of the C-
CC terminal domain (CTD) of the large subunit of RNA polymerase II
CC (POLR2A). {ECO:0000250|UniProtKB:O75909}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75909}.
CC -!- DEVELOPMENTAL STAGE: Widely detected at one day post-fertilization
CC (dpf) and continuously expressed in the brain through development.
CC {ECO:0000269|PubMed:30122539}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes
CC unconsumed yolk sac, small eyes, deformed head, reduced lower jaw size
CC and curly spinal cord at low morpholino doses. High morpholino doses
CC lead to embryonic lethality. {ECO:0000269|PubMed:30122539}.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000255,
CC ECO:0000255|RuleBase:RU000383}.
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DR EMBL; BX649499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU104739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC128853; AAI28854.1; -; mRNA.
DR AlphaFoldDB; F1QMB9; -.
DR SMR; F1QMB9; -.
DR STRING; 7955.ENSDARP00000113893; -.
DR Ensembl; ENSDART00000104581; ENSDARP00000095353; ENSDARG00000034146.
DR ZFIN; ZDB-GENE-030131-5126; ccnk.
DR GeneTree; ENSGT00940000165223; -.
DR Reactome; R-DRE-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR Reactome; R-DRE-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-DRE-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-DRE-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-DRE-75955; RNA Polymerase II Transcription Elongation.
DR PRO; PR:F1QMB9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000034146; Expressed in presomitic mesoderm and 26 other tissues.
DR ExpressionAtlas; F1QMB9; baseline.
DR GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007417; P:central nervous system development; IMP:ZFIN.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Cyclin; Mitosis; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..425
FT /note="Cyclin-K"
FT /id="PRO_0000446921"
FT REGION 262..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..305
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..363
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..400
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 10
FT /note="A -> S (in Ref. 2; AAI28854)"
FT /evidence="ECO:0000305"
FT CONFLICT 397..398
FT /note="PP -> SG (in Ref. 2; AAI28854)"
FT /evidence="ECO:0000305"
FT CONFLICT 421..422
FT /note="DD -> EV (in Ref. 2; AAI28854)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 47894 MW; F1CF9FF05386BDF3 CRC64;
MKDGKENSNA TFGSFTTNLD HTKPCWYWDK KDLAHTPSQS DLDPATEARY RREGARFIFD
VGTRLGLHYD TLATGITYFH RFYMFHSFKQ FPRYVTGACC LFLAGKVEET PKKCKDIIKT
ARSLLNDVQF AQFGDDPKEE VMVLERILLQ TIKFDLQVEH PYQFLLRYAK QLKGDKNKVQ
KLVQMAWTFV NDSLCTMLSL QWEPEIIAVA VMYLAGRLCK FDIQEWTSKQ SSRRWWEQFV
QDVPVELLED ICHQILDLYS QGKQPIPQQP PMQDKEKPPP PPAAPPGQSG AQNPPAQPPS
KKNSPQASPP AKIKRQHVSP KDEPKAPAEQ VGSKIPRLES PMPPLPVSQP PERKTPSAIP
APPAEAEPAA ASELDPAQGP APPLPHGAPP PLPHRPPPTE FGGPCSDFLS SVKHKRRYLD
DDRNL
