CCNL1_PONAB
ID CCNL1_PONAB Reviewed; 172 AA.
AC Q5RD50;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Cyclin-L1;
GN Name=CCNL1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing. Functions in association with
CC cyclin-dependent kinases (CDKs). May play a role in the regulation of
CC RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor
CC CDKN1A/p21. {ECO:0000250|UniProtKB:Q9UK58}.
CC -!- SUBUNIT: Interacts with POLR2A via its hyperphosphorylated C-terminal
CC domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12 and
CC CDK13. May form a ternary complex with CDK11B and casein kinase II
CC (CKII). Interacts with pre-mRNA-splicing factors, including at least
CC SRSF1, SRSF2 AND SRSF7/SLU7 (By similarity).
CC {ECO:0000250|UniProtKB:Q9R1Q2, ECO:0000250|UniProtKB:Q9UK58}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9UK58}.
CC Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9UK58}. Note=Found in
CC nuclear intrachromatin granules clusters (IGC), also called nuclear
CC speckles, which are storage compartments for nuclear proteins involved
CC in mRNA processing. {ECO:0000250|UniProtKB:Q9UK58}.
CC -!- DOMAIN: Contains a RS region (arginine-serine dipeptide repeat) within
CC the C-terminal domain which is the hallmark of the SR family of
CC splicing factors. This region probably plays a role in protein-protein
CC interactions (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily.
CC {ECO:0000305}.
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DR EMBL; CR858068; CAH90307.1; -; Transcribed_RNA.
DR AlphaFoldDB; Q5RD50; -.
DR SMR; Q5RD50; -.
DR STRING; 9601.ENSPPYP00000015917; -.
DR Ensembl; ENSPPYT00000039021; ENSPPYP00000028787; ENSPPYG00000014237.
DR eggNOG; KOG0835; Eukaryota.
DR GeneTree; ENSGT00940000159135; -.
DR InParanoid; Q5RD50; -.
DR Proteomes; UP000001595; Chromosome 3.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:UniProt.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR015431; Cyclin_L1.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF64; PTHR10026:SF64; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 3: Inferred from homology;
KW Cyclin; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..172
FT /note="Cyclin-L1"
FT /id="PRO_0000080483"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..168
FT /note="Cyclin-like"
SQ SEQUENCE 172 AA; 18322 MW; 972B0E52D25720E1 CRC64;
MASGPHSTAT AAAAASSAAP SAGGSSSGTT TTTTTTTGGI LIGDRLYSEV SLTIDHSLIP
EERLSPTPSM QDGLDLPSET DLRILGCELI QAAGILLRLP QVAMATGQVL FHRFFYSKSF
VKHSFEIVAM ACINLASKIE EAPRRIRDVI NVFHHLRQLR GKSDQLHLPK PG
