ID   CCNL2_XENTR             Reviewed;         497 AA.
AC   Q5BKF8;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Cyclin-L2;
GN   Name=ccnl2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:Q96S94}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q96S94}.
CC       Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96S94}.
CC   -!- DOMAIN: Contains a RS region (arginine-serine dipeptide repeat) within
CC       the C-terminal domain which is the hallmark of the SR family of
CC       splicing factors. This region probably plays a role in protein-protein
CC       interactions (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC091090; AAH91090.1; -; mRNA.
DR   RefSeq; NP_001025623.1; NM_001030452.1.
DR   AlphaFoldDB; Q5BKF8; -.
DR   SMR; Q5BKF8; -.
DR   STRING; 8364.ENSXETP00000024290; -.
DR   PaxDb; Q5BKF8; -.
DR   PRIDE; Q5BKF8; -.
DR   GeneID; 595011; -.
DR   KEGG; xtr:595011; -.
DR   CTD; 81669; -.
DR   Xenbase; XB-GENE-956522; ccnl2.
DR   eggNOG; KOG0835; Eukaryota.
DR   InParanoid; Q5BKF8; -.
DR   OrthoDB; 1519153at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 2.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR004367; Cyclin_C-dom.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   Pfam; PF02984; Cyclin_C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SMART; SM01332; Cyclin_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cyclin; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..497
FT                   /note="Cyclin-L2"
FT                   /id="PRO_0000080490"
FT   REGION          61..163
FT                   /note="Cyclin-like 1"
FT   REGION          176..260
FT                   /note="Cyclin-like 2"
FT   REGION          293..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..404
FT                   /note="RS"
FT   COMPBIAS        344..358
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..399
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..488
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   497 AA;  56848 MW;  FA6177D97C867AD1 CRC64;
     MAANSSAVSS DGILIGDKLY SGVMISLENC LMAEERCALT PSVVDGIDVN TEIDLRCVGC
     ELVQAAGILL RLPQVAMATG QVLFQRFFYT KSFVKHSMEH VAMACVHLAS KIEEAPRRIR
     DVINVFHRLR QLREKQKSTP LILDQEYVNL KNQIIKAERR VLKELGFCVH VKHPHKIIVM
     YLQVLECERN KHLVQTSWNY MNDSLRTDVF VRFNPETIAC ACIFLAARTL EIPLPNRPHW
     FYLFGASEED IKEICLQILR LYTRKKADVA LLENKVEKRK LFIEEAKAKA KGLLPDGTPR
     LENAPEFSPS LKNDSPKELK ANKPSPLAVH ALKNCKRKVD GTKRPTSSSP VNGRVSKGRD
     SRSGSRSRDQ SYSRSQSRSQ SPKRRKSQSY SPSSDSKSRS PSRSRSDSPP HKPNHGSYKS
     TKGHVYGNNS DYKYQGHKRR SRSRSSSPSH SRSRESSDSG KYKKKDHYYR RERSRSYDRV
     SHRGYDREYH GHSHHRR