CCNP_HUMAN
ID CCNP_HUMAN Reviewed; 307 AA.
AC Q9H8S5; B4DX65;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Cyclin-P {ECO:0000305};
DE AltName: Full=Cyclin N-terminal domain-containing protein 2;
GN Name=CCNP {ECO:0000312|HGNC:HGNC:25805}; Synonyms=CNTD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Ovary, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=28860486; DOI=10.1038/s41598-017-10770-8;
RA Gasa L., Sanchez-Botet A., Quandt E., Hernandez-Ortega S., Jimenez J.,
RA Carrasco-Garcia M.A., Simonetti S., Kron S.J., Ribeiro M.P., Nadal E.,
RA Villanueva A., Clotet J.;
RT "A systematic analysis of orphan cyclins reveals CNTD2 as a new oncogenic
RT driver in lung cancer.";
RL Sci. Rep. 7:10228-10228(2017).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=30087414; DOI=10.1038/s41598-018-30307-x;
RA Sanchez-Botet A., Gasa L., Quandt E., Hernandez-Ortega S., Jimenez J.,
RA Mezquita P., Carrasco-Garcia M.A., Kron S.J., Vidal A., Villanueva A.,
RA Ribeiro M.P.C., Clotet J.;
RT "The atypical cyclin CNTD2 promotes colon cancer cell proliferation and
RT migration.";
RL Sci. Rep. 8:11797-11797(2018).
CC -!- FUNCTION: Seems to be involved in the regulation of proliferation and
CC migration. {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28860486,
CC ECO:0000269|PubMed:30087414}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H8S5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H8S5-2; Sequence=VSP_044165, VSP_044166, VSP_044167;
CC -!- TISSUE SPECIFICITY: Expression is induced in lung and colon cancer
CC cells. {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK023327; BAB14529.1; -; mRNA.
DR EMBL; AK301833; BAG63277.1; -; mRNA.
DR EMBL; AC118344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS12551.2; -. [Q9H8S5-1]
DR RefSeq; NP_079153.2; NM_024877.3. [Q9H8S5-1]
DR AlphaFoldDB; Q9H8S5; -.
DR SMR; Q9H8S5; -.
DR STRING; 9606.ENSP00000396755; -.
DR iPTMnet; Q9H8S5; -.
DR PhosphoSitePlus; Q9H8S5; -.
DR BioMuta; CNTD2; -.
DR DMDM; 408360026; -.
DR PaxDb; Q9H8S5; -.
DR PRIDE; Q9H8S5; -.
DR Antibodypedia; 57311; 89 antibodies from 20 providers.
DR DNASU; 79935; -.
DR Ensembl; ENST00000221818.5; ENSP00000221818.1; ENSG00000105219.10. [Q9H8S5-2]
DR Ensembl; ENST00000430325.7; ENSP00000396755.2; ENSG00000105219.10. [Q9H8S5-1]
DR GeneID; 79935; -.
DR KEGG; hsa:79935; -.
DR MANE-Select; ENST00000430325.7; ENSP00000396755.2; NM_024877.4; NP_079153.2.
DR UCSC; uc010xvi.2; human. [Q9H8S5-1]
DR CTD; 79935; -.
DR DisGeNET; 79935; -.
DR GeneCards; CCNP; -.
DR HGNC; HGNC:25805; CCNP.
DR HPA; ENSG00000105219; Tissue enhanced (brain, liver).
DR neXtProt; NX_Q9H8S5; -.
DR OpenTargets; ENSG00000105219; -.
DR VEuPathDB; HostDB:ENSG00000105219; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00920000149201; -.
DR HOGENOM; CLU_060971_0_0_1; -.
DR InParanoid; Q9H8S5; -.
DR PhylomeDB; Q9H8S5; -.
DR TreeFam; TF342174; -.
DR PathwayCommons; Q9H8S5; -.
DR SignaLink; Q9H8S5; -.
DR BioGRID-ORCS; 79935; 22 hits in 1064 CRISPR screens.
DR ChiTaRS; CNTD2; human.
DR GenomeRNAi; 79935; -.
DR Pharos; Q9H8S5; Tbio.
DR PRO; PR:Q9H8S5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H8S5; protein.
DR Bgee; ENSG00000105219; Expressed in oocyte and 115 other tissues.
DR ExpressionAtlas; Q9H8S5; baseline and differential.
DR Genevisible; Q9H8S5; HS.
DR GO; GO:0097124; C:cyclin A2-CDK2 complex; IBA:GO_Central.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..307
FT /note="Cyclin-P"
FT /id="PRO_0000263704"
FT DOMAIN 102..203
FT /note="Cyclin N-terminal"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 90..119
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044165"
FT VAR_SEQ 172..185
FT /note="PAFLCLLSADSFSR -> ETEVRNLGPFQGRE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044166"
FT VAR_SEQ 186..307
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044167"
SQ SEQUENCE 307 AA; 33574 MW; 9A5E71ADCE0D63E0 CRC64;
MLVRGRDQGS GSRLGPIVRR WAPRPSPLQS LAASLDAEPS SAAVPDGFPA GPTVSPRRLA
RPPGLEEALS ALGLQGEREY AGDIFAEVMV CRVLPLRALP RAVTPEMRAL VVDWLVQVHE
YLGLAGDTLY LAVHLLDSYL SAGRVRLHRL QLLGVACLFV ACKMEECVLP EPAFLCLLSA
DSFSRAELLR AERRILSRLD FRLHHPGPLL CLGLLAALAG SSPQVMLLAT YFLELSLLEA
EAAGWEPGRR AAAALSLAHR LLDGAGSRLQ PELYRCSLGG GSVWGHRSFR DLPSWSFLRS
RRMRDNY
