ID   CCNQ_MOUSE              Reviewed;         250 AA.
AC   Q8QZR8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Cyclin-Q;
DE   AltName: Full=CDK10-activating cyclin;
DE   AltName: Full=Cyclin-M;
DE   AltName: Full=Cyclin-related protein FAM58A;
DE   AltName: Full=Cyclin-related protein FAM58B;
GN   Name=Ccnq; Synonyms=Fam58a, Fam58b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Activating cyclin for the cyclin-associated kinase CDK10.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with CDK10 to promote its kinase activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin-like FAM58 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL591376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC027022; AAH27022.2; -; mRNA.
DR   CCDS; CCDS25114.1; -.
DR   RefSeq; NP_932106.1; NM_197989.1.
DR   AlphaFoldDB; Q8QZR8; -.
DR   SMR; Q8QZR8; -.
DR   ComplexPortal; CPX-327; Cyclin M-CDK10 complex.
DR   STRING; 10090.ENSMUSP00000050658; -.
DR   PhosphoSitePlus; Q8QZR8; -.
DR   EPD; Q8QZR8; -.
DR   PaxDb; Q8QZR8; -.
DR   PRIDE; Q8QZR8; -.
DR   ProteomicsDB; 281511; -.
DR   Antibodypedia; 73523; 29 antibodies from 12 providers.
DR   DNASU; 69109; -.
DR   Ensembl; ENSMUST00000059468; ENSMUSP00000050658; ENSMUSG00000049489.
DR   GeneID; 69109; -.
DR   KEGG; mmu:69109; -.
DR   UCSC; uc007kjz.1; mouse.
DR   CTD; 92002; -.
DR   MGI; MGI:1916359; Ccnq.
DR   VEuPathDB; HostDB:ENSMUSG00000049489; -.
DR   eggNOG; KOG0834; Eukaryota.
DR   GeneTree; ENSGT00940000155445; -.
DR   HOGENOM; CLU_022000_2_0_1; -.
DR   InParanoid; Q8QZR8; -.
DR   OMA; FDTHVAL; -.
DR   OrthoDB; 958680at2759; -.
DR   PhylomeDB; Q8QZR8; -.
DR   TreeFam; TF101013; -.
DR   BioGRID-ORCS; 69109; 26 hits in 77 CRISPR screens.
DR   PRO; PR:Q8QZR8; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8QZR8; protein.
DR   Bgee; ENSMUSG00000049489; Expressed in ear vesicle and 261 other tissues.
DR   Genevisible; Q8QZR8; MM.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0030295; F:protein kinase activator activity; IDA:MGI.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IGI:MGI.
DR   GO; GO:1902749; P:regulation of cell cycle G2/M phase transition; IC:ComplexPortal.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR028759; Cyclin-Q.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   PANTHER; PTHR10026:SF70; PTHR10026:SF70; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Cyclin; Reference proteome.
FT   CHAIN           1..250
FT                   /note="Cyclin-Q"
FT                   /id="PRO_0000297568"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N1B3"
SQ   SEQUENCE   250 AA;  28928 MW;  7CEC3390E522F54E CRC64;
     MEAVRPDSCE SGPAAPRAEE RPAPEARVHF RVTRFIMEAG VKLGMQSIPI ATACTIYHKF
     FCEINLDAYD LYLVAMSSIY LAGKVEEQHL RTRDIINVSH RYFNPGSEPL ELDSRFWELR
     DSIVQCELLM LRVLRFQVSF QHPHKYLLHY LISLKNWLNR YSWQRTPISV TAWALLRDSY
     HGGLCLRFQA QHLAVAVLYL ALQVYGVEVP AEGEAEKPWW QVFSDDLTKP IIDNIVSDLI
     QIYTMDTEIP