CCNT2_CAEEL
ID CCNT2_CAEEL Reviewed; 555 AA.
AC P34424; Q8IG20;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Cyclin-T1.2;
GN Name=cit-1.2; ORFNames=F44B9.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair
CC (CDK9/cyclin T) complex, also called positive transcription elongation
CC factor B (P-TEFb), which is proposed to facilitate the transition from
CC abortive to production elongation by phosphorylating the CTD (carboxy-
CC terminal domain) of the large subunit of RNA polymerase II (RNAP II).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34424-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34424-2; Sequence=VSP_015982;
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; FO080400; CCD63443.1; -; Genomic_DNA.
DR EMBL; FO080400; CCD63444.1; -; Genomic_DNA.
DR PIR; S44814; S44814.
DR RefSeq; NP_498745.1; NM_066344.4. [P34424-1]
DR RefSeq; NP_871655.1; NM_181926.3.
DR AlphaFoldDB; P34424; -.
DR SMR; P34424; -.
DR BioGRID; 41332; 2.
DR IntAct; P34424; 1.
DR STRING; 6239.F44B9.3a; -.
DR EPD; P34424; -.
DR PaxDb; P34424; -.
DR PeptideAtlas; P34424; -.
DR EnsemblMetazoa; F44B9.3a.1; F44B9.3a.1; WBGene00000508. [P34424-1]
DR EnsemblMetazoa; F44B9.3b.1; F44B9.3b.1; WBGene00000508. [P34424-2]
DR EnsemblMetazoa; F44B9.3b.2; F44B9.3b.2; WBGene00000508. [P34424-2]
DR GeneID; 176126; -.
DR KEGG; cel:CELE_F44B9.3; -.
DR UCSC; F44B9.3b; c. elegans. [P34424-1]
DR CTD; 176126; -.
DR WormBase; F44B9.3a; CE29042; WBGene00000508; cit-1.2. [P34424-1]
DR WormBase; F44B9.3b; CE32417; WBGene00000508; cit-1.2. [P34424-2]
DR eggNOG; KOG0834; Eukaryota.
DR GeneTree; ENSGT00970000196489; -.
DR HOGENOM; CLU_036123_0_0_1; -.
DR InParanoid; P34424; -.
DR OMA; TAYYMAT; -.
DR OrthoDB; 1437076at2759; -.
DR SignaLink; P34424; -.
DR PRO; PR:P34424; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000508; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:UniProtKB.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR GO; GO:1901407; P:regulation of phosphorylation of RNA polymerase II C-terminal domain; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Cyclin; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..555
FT /note="Cyclin-T1.2"
FT /id="PRO_0000080497"
FT REGION 292..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..174
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015982"
SQ SEQUENCE 555 AA; 63023 MW; 6312E93A7E459FFF CRC64;
MSNSNKLIAE KNGSRYGRMI HPWLRKKQDM LADTPSRREG MTYEEELSKR QQGGVFIFDI
AMQLTHGKGE HGLSGVAATL FNRFFNVHSL KRCDFRDVAA ACVFLAGKNE DAPKKLKYVV
TQLWQFKYPH NKQFQSEQHF LDQCNVVTLI EDVLLKTISF DINVDLPHQY VLKLMRDVEK
GRNVYKDMVK TAYYMATDVL IITDWSVRYS CASIATACVN IAAFFHNINM DDIVPFELSD
RWYRLEDQSM TREEVEAMTK EFLDIFSRNP QFHIGSLKKI DPLGKVKIVG MPPQVSSTVT
PSGSSSNLKK IDLESYKGRP KPLSNSSDSP STRPSFLPDV KNQKVVEQEL MEQRMKEAAQ
QKIHRNGHRP SSSSHPLHHH STSSSASNNS NHQNRSSSGL SAHQHQKPYN EDSRSAKRSM
MYEETNSSKK PRIDYKMSFV ASSSTTIATM HNDHFSQTTH QQNISTYARG VNEMMLNQVA
PPPLMSVSAQ PSTYQKMCME YQRNPADSRH TMSSTQQISP PDEPSPPVSQ ILLPPPPPPP
ILPPRLDEME EGELV
