CCNY_CAEEL
ID CCNY_CAEEL Reviewed; 357 AA.
AC P34624;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2003, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Cyclin-Y {ECO:0000305|PubMed:20510931};
GN Name=cyy-1 {ECO:0000312|WormBase:ZK353.1b};
GN ORFNames=ZK353.1 {ECO:0000312|WormBase:ZK353.1b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, INTERACTION WITH PCT-1, AND DISRUPTION PHENOTYPE.
RX PubMed=20510931; DOI=10.1016/j.cell.2010.04.011;
RA Ou C.Y., Poon V.Y., Maeder C.I., Watanabe S., Lehrman E.K., Fu A.K.,
RA Park M., Fu W.Y., Jorgensen E.M., Ip N.Y., Shen K.;
RT "Two cyclin-dependent kinase pathways are essential for polarized
RT trafficking of presynaptic components.";
RL Cell 141:846-858(2010).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21609829; DOI=10.1016/j.neuron.2011.04.002;
RA Park M., Watanabe S., Poon V.Y., Ou C.Y., Jorgensen E.M., Shen K.;
RT "CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and
RT formation for rewiring neural circuits.";
RL Neuron 70:742-757(2011).
CC -!- FUNCTION: In association with pct-1, regulates the trafficking of
CC synaptic vesicle precursors in DA motor neurons by promoting
CC anterograde trafficking to the axon and preventing dynein-dependent
CC trafficking to the dendrite. May also regulate synaptic vesicle
CC trafficking in DD motor neurons and in RIA interneurons
CC (PubMed:20510931). Involved in synapse formation during DD motor neuron
CC remodeling by disassembling ventral presynaptic structures
CC (PubMed:21609829). May activate cdk-5 (PubMed:20510931).
CC {ECO:0000269|PubMed:20510931, ECO:0000269|PubMed:21609829}.
CC -!- SUBUNIT: Interacts with pct-1; the interaction is required to activate
CC pct-1. {ECO:0000269|PubMed:20510931}.
CC -!- INTERACTION:
CC P34624; Q8I7M8: pct-1; NbExp=2; IntAct=EBI-2696495, EBI-2918577;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20510931}. Cell
CC projection, dendrite {ECO:0000269|PubMed:20510931}. Cell projection,
CC axon {ECO:0000269|PubMed:20510931}. Note=Enriched in the dendrite and
CC the proximal axon of the DA motor neuron.
CC {ECO:0000269|PubMed:20510931}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=P34624-1; Sequence=Displayed;
CC Name=a;
CC IsoId=P34624-2; Sequence=VSP_002453;
CC -!- DISRUPTION PHENOTYPE: Abnormal localization of synaptic vesicle
CC components and active zone proteins in the cell body and in the
CC dentrite of DA9 motor neuron (PubMed:20510931). In L4 mutants,
CC incomplete elimination of ventral rab-3-positive synaptic vesicles and
CC small reduction in the formation of dorsal rab-3-positive synaptic
CC vesicles in DD motor neurons, although formation of ventral synapses at
CC the L1 stage is normal (PubMed:21609829). No other phenotype except a
CC slightly smaller progeny size (PubMed:20510931).
CC {ECO:0000269|PubMed:20510931, ECO:0000269|PubMed:21609829}.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO081668; CCD73200.1; -; Genomic_DNA.
DR EMBL; FO081668; CCD73201.1; -; Genomic_DNA.
DR RefSeq; NP_498857.2; NM_066456.4. [P34624-1]
DR RefSeq; NP_498858.2; NM_066457.3. [P34624-2]
DR AlphaFoldDB; P34624; -.
DR BioGRID; 41392; 1.
DR ComplexPortal; CPX-4962; CyclinY-CDK17 complex.
DR IntAct; P34624; 1.
DR STRING; 6239.ZK353.1b; -.
DR iPTMnet; P34624; -.
DR EPD; P34624; -.
DR PaxDb; P34624; -.
DR PeptideAtlas; P34624; -.
DR EnsemblMetazoa; ZK353.1a.1; ZK353.1a.1; WBGene00022697. [P34624-2]
DR EnsemblMetazoa; ZK353.1b.1; ZK353.1b.1; WBGene00022697. [P34624-1]
DR GeneID; 176188; -.
DR KEGG; cel:CELE_ZK353.1; -.
DR UCSC; ZK353.1b; c. elegans. [P34624-1]
DR CTD; 176188; -.
DR WormBase; ZK353.1a; CE34452; WBGene00022697; cyy-1. [P34624-2]
DR WormBase; ZK353.1b; CE34453; WBGene00022697; cyy-1. [P34624-1]
DR eggNOG; KOG1675; Eukaryota.
DR GeneTree; ENSGT00940000154453; -.
DR InParanoid; P34624; -.
DR OMA; PEHKQIY; -.
DR OrthoDB; 916284at2759; -.
DR PhylomeDB; P34624; -.
DR PRO; PR:P34624; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022697; Expressed in embryo and 4 other tissues.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:ComplexPortal.
DR GO; GO:0030425; C:dendrite; IDA:WormBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0008089; P:anterograde axonal transport; IC:ComplexPortal.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051964; P:negative regulation of synapse assembly; IMP:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:1904799; P:regulation of neuron remodeling; IMP:UniProtKB.
DR GO; GO:0045859; P:regulation of protein kinase activity; IBA:GO_Central.
DR GO; GO:2000331; P:regulation of terminal button organization; IMP:UniProtKB.
DR GO; GO:0048489; P:synaptic vesicle transport; IC:ComplexPortal.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR012399; Cyclin_Y.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF028934; Cyclin_CG14939; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cell projection; Cyclin;
KW Cytoplasm; Neurogenesis; Reference proteome; Transport.
FT CHAIN 1..357
FT /note="Cyclin-Y"
FT /id="PRO_0000080516"
FT DOMAIN 186..284
FT /note="Cyclin N-terminal"
FT /evidence="ECO:0000255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 34..35
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_002453"
SQ SEQUENCE 357 AA; 41507 MW; 2E3D64E06B293984 CRC64;
MGNSSCCLRT RSSSGEDKSY NNDGQYIRTN QVEFQYVNQV FPRDETSTNF LPHISEREVT
EGYEEDPSTN PTARPTFMER SKSEMKLKDN RRSCYMLDAL AAGGHHPGIL PRSLRKSSSC
STIYIDDSTV SQPHLKNTIK CISLAIYYHI SNRKNRGHER LMEIFEERLH PIFRDPIPPE
QMTRDPDHRN IYRFVRNLFS SAQLTAECAI ITLVYIERLL NYAEMDLCPS NWRRVVLGSI
MLASKVWDDQ AVWNVDYCQI LRDTNVDDMN ELERRFLECL DFNIEVPSSV YAKYYFDLRT
LALANDLQLP IQPLYKERAQ RLEALSRVFE DKIQSSSLPK RARSAEHLVF EHPAVLS
