ID   CCPA_STAAC              Reviewed;         329 AA.
AC   Q5HF38;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Catabolite control protein A;
GN   Name=ccpA; OrderedLocusNames=SACOL1786;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC       repression (CCR) and carbon catabolite activation (CCA), which ensures
CC       optimal energy usage under diverse conditions. {ECO:0000250}.
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DR   EMBL; CP000046; AAW38314.1; -; Genomic_DNA.
DR   RefSeq; WP_000219066.1; NC_002951.2.
DR   AlphaFoldDB; Q5HF38; -.
DR   SMR; Q5HF38; -.
DR   EnsemblBacteria; AAW38314; AAW38314; SACOL1786.
DR   KEGG; sac:SACOL1786; -.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; HSEFVFM; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006377; CcpA.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR01481; ccpA; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Catabolite control protein A"
FT                   /id="PRO_0000107926"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   329 AA;  36060 MW;  1D5ACFD4F34C85B4 CRC64;
     MTVTIYDVAR EARVSMATVS RVVNGNQNVK AETKNKVNEV IKRLNYRPNA VARGLASKKT
     TTVGVIIPDI SNIYYSQLAR GLEDIATMYK YHSIISNSDN DPEKEKEIFN NLLSKQVDGI
     IFLGGTITEE MKELINQSSV PVVVSGTNGK DAHIASVNID FTEAAKEITG ELIEKGAKSF
     ALVGGEHSKK AQEDVLEGLT EVLNKNGLQL GDTLNCSGAE SYKEGVKAFA KMKGNLPDAI
     LCISDEEAIG IMHSAMDAGI KVPEELQIIS FNNTRLVEMV RPQLSSVIQP LYDIGAVGMR
     LLTKYMNDEK IEEPNVVLPH RIEYRGTTK