ID   CCPA_STAAM              Reviewed;         329 AA.
AC   P67655; Q99TC8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Catabolite control protein A;
GN   Name=ccpA; OrderedLocusNames=SAV1736;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC       repression (CCR) and carbon catabolite activation (CCA), which ensures
CC       optimal energy usage under diverse conditions. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB57898.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB57898.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000219066.1; NC_002758.2.
DR   AlphaFoldDB; P67655; -.
DR   SMR; P67655; -.
DR   World-2DPAGE; 0002:P67655; -.
DR   PaxDb; P67655; -.
DR   EnsemblBacteria; BAB57898; BAB57898; SAV1736.
DR   KEGG; sav:SAV1736; -.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; HSEFVFM; -.
DR   BioCyc; SAUR158878:SAV_RS09330-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006377; CcpA.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR01481; ccpA; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Catabolite control protein A"
FT                   /id="PRO_0000107927"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   329 AA;  36060 MW;  1D5ACFD4F34C85B4 CRC64;
     MTVTIYDVAR EARVSMATVS RVVNGNQNVK AETKNKVNEV IKRLNYRPNA VARGLASKKT
     TTVGVIIPDI SNIYYSQLAR GLEDIATMYK YHSIISNSDN DPEKEKEIFN NLLSKQVDGI
     IFLGGTITEE MKELINQSSV PVVVSGTNGK DAHIASVNID FTEAAKEITG ELIEKGAKSF
     ALVGGEHSKK AQEDVLEGLT EVLNKNGLQL GDTLNCSGAE SYKEGVKAFA KMKGNLPDAI
     LCISDEEAIG IMHSAMDAGI KVPEELQIIS FNNTRLVEMV RPQLSSVIQP LYDIGAVGMR
     LLTKYMNDEK IEEPNVVLPH RIEYRGTTK