ID   CCPA_STAAR              Reviewed;         329 AA.
AC   Q6GFX2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Catabolite control protein A;
GN   Name=ccpA; OrderedLocusNames=SAR1814;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC       repression (CCR) and carbon catabolite activation (CCA), which ensures
CC       optimal energy usage under diverse conditions. {ECO:0000250}.
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DR   EMBL; BX571856; CAG40805.1; -; Genomic_DNA.
DR   RefSeq; WP_000219061.1; NC_002952.2.
DR   AlphaFoldDB; Q6GFX2; -.
DR   SMR; Q6GFX2; -.
DR   KEGG; sar:SAR1814; -.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; HSEFVFM; -.
DR   OrthoDB; 664909at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006377; CcpA.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR01481; ccpA; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Catabolite control protein A"
FT                   /id="PRO_0000107929"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   329 AA;  36043 MW;  04CE4C42A51E94CD CRC64;
     MTVTIYDVAR EARVSMATVS RVVNGNQNVK AETKNKVNEV IKRLNYRPNA VARGLASKKT
     TTVGVIIPDI SNIYYSQLAR GLEDIAIMYK YHSIISNSDN DPEKEKEIFN NLLSKQVDGI
     IFLGGTITEE MKELINQSSV PVVVSGTNGK DAHIASVNID FTEAAKEITG KLIEKGAKSF
     ALVGGEHSKK AQEDVLAGLT EVLNKNSLQL GDTLNCSGAE SYKEGVKAFA KMKGNLPDAI
     LCISDEEAIG IMHSAMDAGI KVPEELQIIS FNNTRLVEMV RPQLSSVIQP LYDIGAVGMR
     LLTKYMNDEK IEEPNVVLPH RIEYRGTTK