CCPA_STAAW
ID CCPA_STAAW Reviewed; 329 AA.
AC Q8NW33;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Catabolite control protein A;
GN Name=ccpA; OrderedLocusNames=MW1679;
OS Staphylococcus aureus (strain MW2).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=196620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MW2;
RX PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT "Genome and virulence determinants of high virulence community-acquired
RT MRSA.";
RL Lancet 359:1819-1827(2002).
CC -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC repression (CCR) and carbon catabolite activation (CCA), which ensures
CC optimal energy usage under diverse conditions. {ECO:0000250}.
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DR EMBL; BA000033; BAB95544.1; -; Genomic_DNA.
DR RefSeq; WP_000219066.1; NC_003923.1.
DR AlphaFoldDB; Q8NW33; -.
DR SMR; Q8NW33; -.
DR EnsemblBacteria; BAB95544; BAB95544; BAB95544.
DR KEGG; sam:MW1679; -.
DR HOGENOM; CLU_037628_6_0_9; -.
DR OMA; HSEFVFM; -.
DR Proteomes; UP000000418; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR006377; CcpA.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR TIGRFAMs; TIGR01481; ccpA; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..329
FT /note="Catabolite control protein A"
FT /id="PRO_0000107931"
FT DOMAIN 1..57
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 5..24
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ SEQUENCE 329 AA; 36060 MW; 1D5ACFD4F34C85B4 CRC64;
MTVTIYDVAR EARVSMATVS RVVNGNQNVK AETKNKVNEV IKRLNYRPNA VARGLASKKT
TTVGVIIPDI SNIYYSQLAR GLEDIATMYK YHSIISNSDN DPEKEKEIFN NLLSKQVDGI
IFLGGTITEE MKELINQSSV PVVVSGTNGK DAHIASVNID FTEAAKEITG ELIEKGAKSF
ALVGGEHSKK AQEDVLEGLT EVLNKNGLQL GDTLNCSGAE SYKEGVKAFA KMKGNLPDAI
LCISDEEAIG IMHSAMDAGI KVPEELQIIS FNNTRLVEMV RPQLSSVIQP LYDIGAVGMR
LLTKYMNDEK IEEPNVVLPH RIEYRGTTK