ID   CCPA_STAES              Reviewed;         329 AA.
AC   Q8CNV8;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2003, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Catabolite control protein A;
GN   Name=ccpA; OrderedLocusNames=SE_1409;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC       repression (CCR) and carbon catabolite activation (CCA), which ensures
CC       optimal energy usage under diverse conditions. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO05008.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO05008.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_764964.1; NC_004461.1.
DR   RefSeq; WP_001830844.1; NZ_WBME01000009.1.
DR   AlphaFoldDB; Q8CNV8; -.
DR   SMR; Q8CNV8; -.
DR   STRING; 176280.SE_1409; -.
DR   EnsemblBacteria; AAO05008; AAO05008; SE_1409.
DR   GeneID; 50018480; -.
DR   KEGG; sep:SE_1409; -.
DR   PATRIC; fig|176280.10.peg.1376; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006377; CcpA.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR01481; ccpA; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Catabolite control protein A"
FT                   /id="PRO_0000107932"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   329 AA;  36465 MW;  F632399878BA27BE CRC64;
     MTVTIYDVAR EARVSMATVS RVVNGNQNVK PETRNKVNEV IKRLNYRPNA VARGLASKRT
     TTVGVIIPDI SNVYYSQLAR GLEDIATMYK YHSIISNSDN DPEKEKEIFN NLLSKQVDGI
     IFLGGTISEE IKSLINQSSV PVVVSGTDGK DDHIASVNID FKQAAEEATQ YLIEKGAKTF
     SLIGGEYSIK AQDDVLEGLK NVLSQHQLKL DDTLHLTGNE SYKSGIKTFE QLQSNLPDAV
     LCISDEQAIG ILHSAQDAGV KVPEDLQIIS FNNTRLVEMV RPQLSSVIQP LYDIGAVGMR
     LLTKYMNDEE IENPNVILPH RIEYRGTTQ