ID   CCPA_STAXY              Reviewed;         329 AA.
AC   Q56194;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Catabolite control protein A;
GN   Name=ccpA;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=8878037; DOI=10.1046/j.1365-2958.1996.301398.x;
RA   Egeter O., Brueckner R.;
RT   "Catabolite repression mediated by the catabolite control protein CcpA in
RT   Staphylococcus xylosus.";
RL   Mol. Microbiol. 21:739-749(1996).
CC   -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC       repression (CCR) and carbon catabolite activation (CCA), which ensures
CC       optimal energy usage under diverse conditions. {ECO:0000250}.
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DR   EMBL; X95439; CAA64713.1; -; Genomic_DNA.
DR   RefSeq; WP_029377027.1; NZ_VBTJ01000001.1.
DR   AlphaFoldDB; Q56194; -.
DR   SMR; Q56194; -.
DR   STRING; 1288.SXYLSMQ121_1066; -.
DR   GeneID; 45496739; -.
DR   eggNOG; COG1609; Bacteria.
DR   OrthoDB; 664909at2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006377; CcpA.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR01481; ccpA; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..329
FT                   /note="Catabolite control protein A"
FT                   /id="PRO_0000107934"
FT   DOMAIN          1..57
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        5..24
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   329 AA;  36257 MW;  702AA34759A32E9A CRC64;
     MTVTIYDVAR EARVSMATVS RVVNGNQNVK PETRDKVNEV IKKLNYRPNA VARGLASKRT
     TTVGVIIPDI SNVYYSQLAR GLEDIATMYK YHSIISNSDN DPSKEKEIFN NLLSKQVDGI
     IFLGGTISEE IKDLINKSSV PVVVSGTNGK DEGISSVNID FESAAKEITE HLIEKGAKSF
     AFVGGDYSKK AQEDVLVGLK DVLVQHELEL DEQLIFNGNE TYKDGLRAFE SLATAKPDAI
     LSISDEQAIG LVHAAQDAGV NVPNDLQIVS FNNTRLVEMV RPQLSSVIQP LYDIGAVGMR
     LLTKYMNEED IDEPNVILPH RIEYRGTTK