ID   CCPA_STRMU              Reviewed;         333 AA.
AC   O07329;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Catabolite control protein A;
GN   Name=ccpA; OrderedLocusNames=SMU_1591;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GS-5;
RA   Albone E.F., Burne R.A.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT11;
RA   Simpson C.L., Russell R.R.B.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Global transcriptional regulator of carbon catabolite
CC       repression (CCR) and carbon catabolite activation (CCA), which ensures
CC       optimal energy usage under diverse conditions. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF001316; AAB58798.1; -; Genomic_DNA.
DR   EMBL; AF014460; AAC46294.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN59234.1; -; Genomic_DNA.
DR   RefSeq; NP_721928.1; NC_004350.2.
DR   RefSeq; WP_002262797.1; NC_004350.2.
DR   AlphaFoldDB; O07329; -.
DR   SMR; O07329; -.
DR   STRING; 210007.SMU_1591; -.
DR   PRIDE; O07329; -.
DR   EnsemblBacteria; AAN59234; AAN59234; SMU_1591.
DR   KEGG; smu:SMU_1591; -.
DR   PATRIC; fig|210007.7.peg.1416; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_0_9; -.
DR   OMA; HSEFVFM; -.
DR   PhylomeDB; O07329; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006377; CcpA.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   TIGRFAMs; TIGR01481; ccpA; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..333
FT                   /note="Catabolite control protein A"
FT                   /id="PRO_0000107935"
FT   DOMAIN          7..61
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        9..28
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   CONFLICT        264
FT                   /note="K -> R (in Ref. 1; AAB58798)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        327..328
FT                   /note="RE -> KK (in Ref. 1; AAB58798)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="T -> P (in Ref. 2; AAC46294)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   333 AA;  36614 MW;  22A600D1147029F7 CRC64;
     MNTDDTITIY DVAREAGVSM ATVSRVVNGN KNVKENTRKK VLEVIDRLDY RPNAVARGLA
     SKKTTTVGVV IPNIANAYFS ILAKGIDDIA TMYKYNIVLA SSDEDDDKEV NVINTLFAKQ
     VDGIIFMGHH LTEKIRAEFS RARTPVVLSG TVDLEHQLPS VNIDHSKAAQ DAVALLAKHH
     DKIAFVSGPL IDDINGKVRL AGYKEGLKKK GLPFKEGLVF EAQYKYQEGY QLAQRVINSG
     ATAAYVAEDE LAAGLLNGLF AAGKKVPEDF EIITSNDSTI ALYTRPNMTS ISQPIYDLGA
     VAMRMLTKIM NKEELEEKEI VLNHGIRERG TTK