ID   CCPB_BACSU              Reviewed;         311 AA.
AC   P37517;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Catabolite control protein B;
GN   Name=ccpB; Synonyms=yyaG; OrderedLocusNames=BSU40870;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7584024; DOI=10.1093/dnares/1.1.1;
RA   Ogasawara N., Nakai S., Yoshikawa H.;
RT   "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis
RT   chromosome containing the replication origin.";
RL   DNA Res. 1:1-14(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-311.
RC   STRAIN=BD99;
RX   PubMed=8011666; DOI=10.1016/0005-2728(94)90131-7;
RA   Quirk P.G., Guffanti A.A., Clejan S., Cheng J., Krulwich T.A.;
RT   "Isolation of Tn917 insertional mutants of Bacillus subtilis that are
RT   resistant to the protonophore carbonyl cyanide m-chlorophenylhydrazone.";
RL   Biochim. Biophys. Acta 1186:27-34(1994).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=9457849; DOI=10.1128/jb.180.3.491-497.1998;
RA   Chauvaux S., Paulsen I.T., Saier M.H. Jr.;
RT   "CcpB, a novel transcription factor implicated in catabolite repression in
RT   Bacillus subtilis.";
RL   J. Bacteriol. 180:491-497(1998).
CC   -!- FUNCTION: Transcriptional regulator involved in catabolite repression
CC       of several operons.
CC   -!- SUBUNIT: Seems to be complexed to phosphorylated HPr.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D26185; BAA05217.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16124.1; -; Genomic_DNA.
DR   EMBL; L16865; AAA64345.1; -; Genomic_DNA.
DR   PIR; S66011; S66011.
DR   RefSeq; NP_391967.1; NC_000964.3.
DR   RefSeq; WP_003243573.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P37517; -.
DR   SMR; P37517; -.
DR   STRING; 224308.BSU40870; -.
DR   PaxDb; P37517; -.
DR   PRIDE; P37517; -.
DR   DNASU; 937876; -.
DR   EnsemblBacteria; CAB16124; CAB16124; BSU_40870.
DR   GeneID; 937876; -.
DR   KEGG; bsu:BSU40870; -.
DR   PATRIC; fig|224308.179.peg.4428; -.
DR   eggNOG; COG1609; Bacteria.
DR   OMA; PIVCCEN; -.
DR   PhylomeDB; P37517; -.
DR   BioCyc; BSUB:BSU40870-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF00532; Peripla_BP_1; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Catabolite control protein B"
FT                   /id="PRO_0000107936"
FT   DOMAIN          1..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   311 AA;  34847 MW;  0FE84CF14D9388CF CRC64;
     MANIKEIARL ANVSVSTVSR VLNHHPYVSE EKRKLVHQVM KELDYTPNRT AIDLIRGKTH
     TVGVILPYSD HPCFDKIVNG ITKAAFQHEY ATTLLPTNYN PDIEIKYLEL LRTKKIDGLI
     ITSRANHWDS ILAYQEYGPV IACEDTGDID VPCAFNDRKT AYAESFRYLK SRGHENIAFT
     CVREADRSPS TADKAAAYKA VCGRLEDRHM LSGCNDMNDG ELAAEHFYMS GRVPTAIYAN
     SDEVAAGIHL FAKKNNWDVE IIGEGNTSIS RVLGFPSLDL NLEQLGIAAF SLFLQDEPAD
     IKIQHKFKKK A