CCR10_HUMAN
ID CCR10_HUMAN Reviewed; 362 AA.
AC P46092; Q4V749; Q6T7X2; Q9NZG2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 3.
DT 03-AUG-2022, entry version 191.
DE RecName: Full=C-C chemokine receptor type 10;
DE Short=C-C CKR-10;
DE Short=CC-CKR-10;
DE Short=CCR-10;
DE AltName: Full=G-protein coupled receptor 2;
GN Name=CCR10; Synonyms=GPR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=10725696; DOI=10.4049/jimmunol.164.7.3460;
RA Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I.,
RA Gerard C.;
RT "Identification of the orphan receptor G-protein-coupled receptor 2 as
RT CCR10, a specific receptor for the chemokine ESkine.";
RL J. Immunol. 164:3460-3464(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RX PubMed=10725697; DOI=10.4049/jimmunol.164.7.3465;
RA Homey B., Wang W., Soto H., Buchanan M.E., Wiesenborn A., Catron D.,
RA Muller A., McClanahan T.K., Dieu-Nosjean M.C., Orozco R., Ruzicka T.,
RA Lehmann P., Oldham E., Zlotnik A.;
RT "The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10)
RT binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).";
RL J. Immunol. 164:3465-3470(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-362.
RX PubMed=7851889; DOI=10.1006/geno.1994.1549;
RA Marchese A., Docherty J.M., Nguyen T., Heiber M., Cheng R., Heng H.H.Q.,
RA Tsui L.-C., Shi X., George S.R., O'Dowd B.F.;
RT "Cloning of human genes encoding novel G protein-coupled receptors.";
RL Genomics 23:609-618(1994).
RN [6]
RP LIGAND-BINDING, AND TISSUE SPECIFICITY.
RX PubMed=10781587; DOI=10.1074/jbc.m001461200;
RA Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D.,
RA Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J.,
RA Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.;
RT "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).";
RL J. Biol. Chem. 275:22313-22323(2000).
RN [7]
RP LIGAND-BINDING.
RX PubMed=10975800; DOI=10.4049/jimmunol.165.6.2943;
RA Pan J., Kunkel E.J., Gosslar U., Lazarus N., Langdon P., Broadwell K.,
RA Vierra M.A., Genovese M.C., Butcher E.C., Soler D.;
RT "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells
RT in mucosal tissues.";
RL J. Immunol. 165:2943-2949(2000).
CC -!- FUNCTION: Receptor for chemokines SCYA27 and SCYA28. Subsequently
CC transduces a signal by increasing the intracellular calcium ions level
CC and stimulates chemotaxis in a pre-B cell line.
CC -!- INTERACTION:
CC P46092; O15145: ARPC3; NbExp=3; IntAct=EBI-348022, EBI-351829;
CC P46092; P60903: S100A10; NbExp=5; IntAct=EBI-348022, EBI-717048;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in adult testis, small
CC intestine, fetal lung, fetal kidney. Weaker expression was observed in
CC many other adult tissues including spleen, thymus, lymph node, Peyer
CC patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and
CC spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal
CC microvascular endothelial cells. Also detected in T-cells and in skin-
CC derived Langerhans cells. {ECO:0000269|PubMed:10781587}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry;
CC URL="https://en.wikipedia.org/wiki/CC_chemokine_receptors";
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DR EMBL; AF215981; AAF63709.1; -; mRNA.
DR EMBL; AF208237; AAF72871.1; -; mRNA.
DR EMBL; AY429103; AAR07898.1; -; mRNA.
DR EMBL; BC098132; AAH98132.1; -; mRNA.
DR EMBL; BC098157; AAH98157.1; -; mRNA.
DR EMBL; BC098304; AAH98304.1; -; mRNA.
DR EMBL; BC099840; AAH99840.1; -; mRNA.
DR EMBL; U13667; AAA64593.1; -; Genomic_DNA.
DR CCDS; CCDS11435.1; -.
DR PIR; B55733; B55733.
DR RefSeq; NP_057686.2; NM_016602.2.
DR AlphaFoldDB; P46092; -.
DR SMR; P46092; -.
DR BioGRID; 109087; 3.
DR DIP; DIP-5873N; -.
DR IntAct; P46092; 10.
DR STRING; 9606.ENSP00000332504; -.
DR BindingDB; P46092; -.
DR ChEMBL; CHEMBL2321628; -.
DR GuidetoPHARMACOLOGY; 67; -.
DR iPTMnet; P46092; -.
DR PhosphoSitePlus; P46092; -.
DR BioMuta; CCR10; -.
DR DMDM; 62298314; -.
DR MassIVE; P46092; -.
DR MaxQB; P46092; -.
DR PaxDb; P46092; -.
DR PeptideAtlas; P46092; -.
DR PRIDE; P46092; -.
DR ProteomicsDB; 55718; -.
DR Antibodypedia; 3185; 429 antibodies from 37 providers.
DR DNASU; 2826; -.
DR Ensembl; ENST00000332438.4; ENSP00000332504.4; ENSG00000184451.5.
DR GeneID; 2826; -.
DR KEGG; hsa:2826; -.
DR MANE-Select; ENST00000332438.4; ENSP00000332504.4; NM_016602.3; NP_057686.2.
DR UCSC; uc002iax.5; human.
DR CTD; 2826; -.
DR DisGeNET; 2826; -.
DR GeneCards; CCR10; -.
DR HGNC; HGNC:4474; CCR10.
DR HPA; ENSG00000184451; Tissue enhanced (pituitary).
DR MIM; 600240; gene.
DR neXtProt; NX_P46092; -.
DR OpenTargets; ENSG00000184451; -.
DR PharmGKB; PA28862; -.
DR VEuPathDB; HostDB:ENSG00000184451; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234667; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P46092; -.
DR OMA; MLPELCE; -.
DR OrthoDB; 1082304at2759; -.
DR PhylomeDB; P46092; -.
DR TreeFam; TF330966; -.
DR PathwayCommons; P46092; -.
DR Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; P46092; -.
DR BioGRID-ORCS; 2826; 18 hits in 1077 CRISPR screens.
DR ChiTaRS; CCR10; human.
DR GeneWiki; CCR10; -.
DR GenomeRNAi; 2826; -.
DR Pharos; P46092; Tchem.
DR PRO; PR:P46092; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P46092; protein.
DR Bgee; ENSG00000184451; Expressed in sural nerve and 107 other tissues.
DR ExpressionAtlas; P46092; baseline and differential.
DR Genevisible; P46092; HS.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR005382; Chemokine_CCR10.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF773; PTHR10489:SF773; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01557; CHEMOKINER10.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..362
FT /note="C-C chemokine receptor type 10"
FT /id="PRO_0000069293"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..114
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..269
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..313
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 328..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 113..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 51
FT /note="V -> L (in Ref. 5; AAA64593)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="Missing (in Ref. 2; AAF72871)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="C -> S (in Ref. 1 and 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 362 AA; 38416 MW; 736EB9B639AEA99A CRC64;
MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG
LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY
SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS
QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP
ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL
ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW
DN
