CCR10_MOUSE
ID CCR10_MOUSE Reviewed; 362 AA.
AC Q9JL21; Q542A4; Q9JIP1; Q9JL20;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=C-C chemokine receptor type 10;
DE Short=C-C CKR-10;
DE Short=CC-CKR-10;
DE Short=CCR-10;
DE AltName: Full=Chemokine C-C receptor 9;
DE AltName: Full=G-protein coupled receptor 2;
GN Name=Ccr10; Synonyms=Cmkbr9, Gpr2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC STRAIN=BALB/cJ; TISSUE=Peyer patch;
RX PubMed=10725696; DOI=10.4049/jimmunol.164.7.3460;
RA Jarmin D.I., Rits M., Bota D., Gerard N.P., Graham G.J., Clark-Lewis I.,
RA Gerard C.;
RT "Identification of the orphan receptor G-protein-coupled receptor 2 as
RT CCR10, a specific receptor for the chemokine ESkine.";
RL J. Immunol. 164:3460-3464(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND LIGAND-BINDING.
RC TISSUE=Thymocyte;
RX PubMed=10781587; DOI=10.1074/jbc.m001461200;
RA Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D.,
RA Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J.,
RA Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.;
RT "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).";
RL J. Biol. Chem. 275:22313-22323(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymocyte;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for chemokines SCYA27 and SCYA28. Subsequently
CC transduces a signal by increasing the intracellular calcium ions level.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in small intestine, colon,
CC lymph nodes, Peyer patches and at lower levels in thymus, lung and
CC spleen. {ECO:0000269|PubMed:10781587}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF215982; AAF63710.1; -; mRNA.
DR EMBL; AF215983; AAF63711.1; -; mRNA.
DR EMBL; AF208238; AAF72872.1; -; mRNA.
DR EMBL; AK090044; BAC41062.1; -; mRNA.
DR EMBL; AL590969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466677; EDL03895.1; -; Genomic_DNA.
DR EMBL; BC117043; AAI17044.1; -; mRNA.
DR EMBL; BC120542; AAI20543.1; -; mRNA.
DR CCDS; CCDS25454.1; -.
DR RefSeq; NP_031747.2; NM_007721.4.
DR AlphaFoldDB; Q9JL21; -.
DR SMR; Q9JL21; -.
DR STRING; 10090.ENSMUSP00000062588; -.
DR BindingDB; Q9JL21; -.
DR ChEMBL; CHEMBL3879821; -.
DR GuidetoPHARMACOLOGY; 67; -.
DR iPTMnet; Q9JL21; -.
DR PhosphoSitePlus; Q9JL21; -.
DR PaxDb; Q9JL21; -.
DR PRIDE; Q9JL21; -.
DR ProteomicsDB; 281429; -.
DR Antibodypedia; 3185; 429 antibodies from 37 providers.
DR DNASU; 12777; -.
DR Ensembl; ENSMUST00000062759; ENSMUSP00000062588; ENSMUSG00000044052.
DR GeneID; 12777; -.
DR KEGG; mmu:12777; -.
DR UCSC; uc007lns.1; mouse.
DR CTD; 2826; -.
DR MGI; MGI:1096320; Ccr10.
DR VEuPathDB; HostDB:ENSMUSG00000044052; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234667; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q9JL21; -.
DR OMA; MLPELCE; -.
DR OrthoDB; 1082304at2759; -.
DR PhylomeDB; Q9JL21; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 12777; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9JL21; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9JL21; protein.
DR Bgee; ENSMUSG00000044052; Expressed in small intestine Peyer's patch and 25 other tissues.
DR Genevisible; Q9JL21; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA:MGI.
DR GO; GO:0004950; F:chemokine receptor activity; IDA:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:MGI.
DR InterPro; IPR005382; Chemokine_CCR10.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF773; PTHR10489:SF773; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01557; CHEMOKINER10.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..362
FT /note="C-C chemokine receptor type 10"
FT /id="PRO_0000069294"
FT TOPO_DOM 1..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..291
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 113..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 135
FT /note="S -> N (in Ref. 1; AAF63710/AAF63711)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 362 AA; 38900 MW; 13C4292859C376CE CRC64;
MGTKPTEQVS WGLYSGYDEE AYSVGPLPEL CYKADVQAFS RAFQPSVSLM VAVLGLAGNG
LVLATHLAAR RTTRSPTSVH LLQLALADLL LALTLPFAAA GALQGWNLGS TTCRAISGLY
SASFHAGFLF LACISADRYV AIARALPAGQ RPSTPSRAHL VSVFVWLLSL FLALPALLFS
RDGPREGQRR CRLIFPESLT QTVKGASAVA QVVLGFALPL GVMAACYALL GRTLLAARGP
ERRRALRVVV ALVVAFVVLQ LPYSLALLLD TADLLAARER SCSSSKRKDL ALLVTGGLTL
VRCSLNPVLY AFLGLRFRRD LRRLLQGGGC SPKPNPRGRC PRRLRLSSCS APTETHSLSW
DN