CCR3_CANLF
ID CCR3_CANLF Reviewed; 359 AA.
AC Q64H34; Q5KSV7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=C-C chemokine receptor type 3;
DE Short=C-C CKR-3;
DE Short=CC-CKR-3;
DE Short=CCR-3;
DE Short=CCR3;
DE Short=CKR3;
DE AltName: CD_antigen=CD193;
GN Name=CCR3; Synonyms=CMKBR3;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Peters I.R., Peeters D., Clercx C., Day M.J.;
RT "Identification of coding sequences for canine monocyte chemotactic
RT protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine
RT receptor 3 (CCR3).";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Tsukui T., Maeda S., Koyanagi M., Hashimoto R., Masuda K., Ohno K.,
RA Sakaguchi M., Tsujimoto H., Iwabuchi S.;
RT "Expression analysis of CCR3 gene in canine atopic dermatitis.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for C-C type chemokine. Binds and responds to a
CC variety of chemokines, including CCL11, CCL26, CCL7, CCL13,
CC RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing
CC the intracellular calcium ions level. In addition acts as a possible
CC functional receptor for NARS1. {ECO:0000250|UniProtKB:P51677}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY675237; AAU14062.1; -; mRNA.
DR EMBL; AB183193; BAD83841.1; -; mRNA.
DR RefSeq; NP_001005261.1; NM_001005261.1.
DR AlphaFoldDB; Q64H34; -.
DR SMR; Q64H34; -.
DR STRING; 9615.ENSCAFP00000020344; -.
DR PaxDb; Q64H34; -.
DR GeneID; 448802; -.
DR KEGG; cfa:448802; -.
DR CTD; 1232; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q64H34; -.
DR OMA; DMGLLCE; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR002238; Chemokine_CCR3.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01108; CHEMOKINER3.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="C-C chemokine receptor type 3"
FT /id="PRO_0000069236"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 89
FT /note="F -> S (in Ref. 2; BAD83841)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="L -> S (in Ref. 2; BAD83841)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="H -> D (in Ref. 2; BAD83841)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="F -> L (in Ref. 2; BAD83841)"
FT /evidence="ECO:0000305"
FT CONFLICT 261
FT /note="L -> R (in Ref. 2; BAD83841)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 41496 MW; 7F8D6EB5D98615D2 CRC64;
MEATTAEIKT MDESIQTTVF DYENSLPCEK VNIKHLGAQF LPPLYSLVFV IGLLGNVVVV
VILTKYKRLW IMTNIFLLNL AISDLLFLFT LVFWIHYTGW NDWVFGRSMC KLISGLYYLG
LYGEIFFIIL LTIDRYLAIV HAVFALRART VTFGIITSVL TWGLAGLAAL PEFIFHESQK
ESEQFVCTPL YPKDQEDNWK RFHALRMNIL GLALPLLIMV VCYSGIIKTL LRCPSKKKYK
AIRLIFVIMV VFFIFWTPYN LVLLLSAFQT IFFETTCEQS KQLDVAMQIT EVIAYTHCCI
NPIIYAFVGE RFRKHLCHFF RRNVATYLGK YIPFLPSEKL ERSSSVSPST GEQEFSFVF
