CCR3_CAVPO
ID CCR3_CAVPO Reviewed; 358 AA.
AC Q9Z2I3;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=C-C chemokine receptor type 3;
DE Short=C-C CKR-3;
DE Short=CC-CKR-3;
DE Short=CCR-3;
DE Short=CCR3;
DE Short=CKR3;
DE AltName: CD_antigen=CD193;
GN Name=CCR3; Synonyms=CMKBR3;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9834099;
RA Sabroe I., Conroy D.M., Gerard N.P., Li Y., Collins P.D., Post T.W.,
RA Jose P.J., Williams T.J., Gerard C.J., Ponath P.D.;
RT "Cloning and characterization of the guinea pig eosinophil eotaxin
RT receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in
RT vivo.";
RL J. Immunol. 161:6139-6147(1998).
CC -!- FUNCTION: Receptor for C-C type chemokine. Binds and responds to a
CC variety of chemokines, including CCL11, CCL26, CCL7, CCL13,
CC RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing
CC the intracellular calcium ions level. In addition acts as a possible
CC functional receptor for NARS1. {ECO:0000250|UniProtKB:P51677}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF060698; AAC80428.1; -; Genomic_DNA.
DR RefSeq; XP_013015509.1; XM_013160055.1.
DR RefSeq; XP_013015510.1; XM_013160056.1.
DR RefSeq; XP_013015511.1; XM_013160057.1.
DR AlphaFoldDB; Q9Z2I3; -.
DR SMR; Q9Z2I3; -.
DR STRING; 10141.ENSCPOP00000016457; -.
DR Ensembl; ENSCPOT00000012621; ENSCPOP00000016457; ENSCPOG00000012502.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q9Z2I3; -.
DR OMA; DMGLLCE; -.
DR OrthoDB; 900867at2759; -.
DR TreeFam; TF330966; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012502; Expressed in pituitary gland and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019957; F:C-C chemokine binding; IEA:Ensembl.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR InterPro; IPR002238; Chemokine_CCR3.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01108; CHEMOKINER3.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..358
FT /note="C-C chemokine receptor type 3"
FT /id="PRO_0000069237"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 358 AA; 41623 MW; 7B73FAB7A3BC3670 CRC64;
MATYPEEAEL ETEFPGTTFY DYEFAQPCFK VSITDLGAQF LPSLFSLVFI VGLLGNITVI
VVLTKYQKLK IMTNIYLLNL AISDLLFLFT LPFWTYYVHW NKWVFGHFMC KIISGLYYVG
LFSEIFFIIL LTIDRYLAIV HAVFALRTRT VTFGIITSVI TWVLAVLAAL PEFMFYGTQG
HFEVLFCGPS YPEKKEHHWK RFQALRMNIF GLALPLLIMI ICYTGIIKTL LRCPSKKKYK
AIRLIFVIMV VFFVFWTPYN LLLLFSAFDL SFLDDCERSK QLDMAKHVTE VIAHTHCCIN
PIIYAFVGER FQKYLRHFLH RNVTMHLSKY IPFFTSEKLE RSSSISPSSG DPELSVVF
