ID   CCR3_CHLAE              Reviewed;         355 AA.
AC   P56492;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=C-C chemokine receptor type 3;
DE            Short=C-C CKR-3;
DE            Short=CC-CKR-3;
DE            Short=CCR-3;
DE            Short=CCR3;
DE            Short=CKR3;
DE   AltName: CD_antigen=CD193;
GN   Name=CCR3; Synonyms=CMKBR3;
OS   Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=9534;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Sol N., Treboute C., Gomas E., Ferchal F., Alizon M.;
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for a C-C type chemokine. Binds to eotaxin, MCP-3,
CC       MCP-4 and RANTES and subsequently transduces a signal by increasing the
CC       intracellular calcium ions level.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; Y13775; CAA74106.1; -; Genomic_DNA.
DR   AlphaFoldDB; P56492; -.
DR   SMR; P56492; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR002238; Chemokine_CCR3.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01108; CHEMOKINER3.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..355
FT                   /note="C-C chemokine receptor type 3"
FT                   /id="PRO_0000069238"
FT   TOPO_DOM        1..34
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..62
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..203
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..264
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..305
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..355
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        106..183
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   355 AA;  40831 MW;  44F7A5EFEEB978FF CRC64;
     MTTSLYTVET FGPTSYDDDM GLLCEKADVG ALIAQFVPPL YSLVFTVGLL GNVVVVMILI
     KYRRLRIMTN IYLLNLAISD LLFLFTLPFW IHYVREHNWV FSHGMCKVLS GFYHTGLYSE
     IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLVALPEFI FYGTEELFPE
     TLCSAIYPQD TVYSWRHFHT LKMTILCLAL PLLVMAICYT GIIKTLLKCP SKKKYKAIRL
     IFVIMAVFFI FWTPYNVAIL ISTYQSILFG LDCERSKHVD LVVLVTEVIA YSHCCVNPVI
     YAFVGERFRK YLRHFFHRHV LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LCIVF