CCR3_MACFA
ID CCR3_MACFA Reviewed; 355 AA.
AC Q9BDS8;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=C-C chemokine receptor type 3;
DE Short=C-C CKR-3;
DE Short=CC-CKR-3;
DE Short=CCR-3;
DE Short=CCR3;
DE Short=CKR3;
DE AltName: CD_antigen=CD193;
GN Name=CCR3; Synonyms=CMKBR3;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11242524; DOI=10.1089/08892220150503744;
RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.;
RT "Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33:
RT potential coreceptors for HIV type 1, HIV type 2, and SIV.";
RL AIDS Res. Hum. Retroviruses 17:371-375(2001).
CC -!- FUNCTION: Receptor for C-C type chemokine. Binds and responds to a
CC variety of chemokines, including CCL11, CCL26, CCL7, CCL13,
CC RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing
CC the intracellular calcium ions level. In addition acts as a possible
CC functional receptor for NARS1. {ECO:0000250|UniProtKB:P51677}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291668; AAK25739.1; -; mRNA.
DR AlphaFoldDB; Q9BDS8; -.
DR SMR; Q9BDS8; -.
DR STRING; 9541.XP_005546955.1; -.
DR BindingDB; Q9BDS8; -.
DR ChEMBL; CHEMBL1075262; -.
DR eggNOG; KOG3656; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR InterPro; IPR002238; Chemokine_CCR3.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01108; CHEMOKINER3.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..355
FT /note="C-C chemokine receptor type 3"
FT /id="PRO_0000069240"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 106..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 355 AA; 40915 MW; 2B7865A177D261CE CRC64;
MTTSLDTVET FGPTSYDDDM GLLCEKADVG ALIAQFVPPL YSLVFMVGLL GNVVVVMILI
KYRRLRIMTN IYLLNLAISD LLFLFTLPFW IHYVRERNWV FSHGMCKVLS GFYHTGLYSE
IFFIILLTID RYLAIVHAVF ALRARTVTFG VVTSIVTWGL AVLAALPEFI FYGTEELFPE
TLCSAIYPQD TVYSWRHFHT LRMTILCLAL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL
IFVIMAVFFI FWTPYNVAIL ISTYQSILFG PDCERSKHLD LFVLVTEVIA YSHCWVNPVI
YAFVGERFRK YLRHFFHRHV LMHPGKYIPF LPSEKLERTS SVSPSTAEPE LSIVF
