CCR3_RAT
ID CCR3_RAT Reviewed; 359 AA.
AC O54814; O55169;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=C-C chemokine receptor type 3;
DE Short=C-C CKR-3;
DE Short=CC-CKR-3;
DE Short=CCR-3;
DE Short=CCR3;
DE Short=CKR3;
DE AltName: CD_antigen=CD193;
GN Name=Ccr3; Synonyms=Cmkbr3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RC STRAIN=Wistar; TISSUE=Spleen;
RX PubMed=9655467; DOI=10.1016/s0165-5728(98)00005-8;
RA Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K.,
RA deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K.;
RT "Chemokine receptor expression in cultured glia and rat experimental
RT allergic encephalomyelitis.";
RL J. Neuroimmunol. 86:1-12(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Wistar; TISSUE=Spleen;
RA Harrington P.M., Newton D.J., Coleman J.W., Flanagan B.F.;
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for C-C type chemokine. Binds and responds to a
CC variety of chemokines, including CCL11, CCL26, CCL7, CCL13,
CC RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing
CC the intracellular calcium ions level. In addition acts as a possible
CC functional receptor for NARS1. {ECO:0000250|UniProtKB:P51677}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in spleen but not in astrocytes or
CC microglia. {ECO:0000269|PubMed:9655467}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF003954; AAC03337.1; -; Genomic_DNA.
DR EMBL; Y13400; CAA73830.1; -; mRNA.
DR RefSeq; NP_446410.1; NM_053958.1.
DR AlphaFoldDB; O54814; -.
DR SMR; O54814; -.
DR STRING; 10116.ENSRNOP00000008809; -.
DR BindingDB; O54814; -.
DR ChEMBL; CHEMBL3928; -.
DR PhosphoSitePlus; O54814; -.
DR PaxDb; O54814; -.
DR GeneID; 117027; -.
DR KEGG; rno:117027; -.
DR UCSC; RGD:620593; rat.
DR CTD; 1232; -.
DR RGD; 620593; Ccr3.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; O54814; -.
DR OrthoDB; 900867at2759; -.
DR PhylomeDB; O54814; -.
DR TreeFam; TF330966; -.
DR Reactome; R-RNO-380108; Chemokine receptors bind chemokines.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:O54814; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IDA:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0019957; F:C-C chemokine binding; ISO:RGD.
DR GO; GO:0016493; F:C-C chemokine receptor activity; ISO:RGD.
DR GO; GO:0004950; F:chemokine receptor activity; TAS:RGD.
DR GO; GO:0035476; P:angioblast cell migration; IMP:RGD.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; ISO:RGD.
DR GO; GO:0048245; P:eosinophil chemotaxis; IMP:RGD.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IGI:RGD.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0002551; P:mast cell chemotaxis; IMP:RGD.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:RGD.
DR InterPro; IPR002238; Chemokine_CCR3.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01108; CHEMOKINER3.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="C-C chemokine receptor type 3"
FT /id="PRO_0000069243"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 164
FT /note="F -> L (in Ref. 2; CAA73830)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 41643 MW; 880F682984F501DA CRC64;
MASNEEELKT VVETFETTPY EYEWAPPCEK VSIRELGSWL LPPLYSLVFI VGLLGNMMVV
LILIKYRKLQ IMTNIYLLNL AISDLLFLFT VPFWIHYVLW NEWGFGHCMC KMLSGLYYLA
LYSEIFFIIL LTIDRYLAIV HAVLALRART VTFATITSII TWGFAVLAAL PEFIFHESQD
NFGDLSCSPR YPEGEEDSWK RFHALRMNIF GLALPLLIMV ICYSGIIKTL LRCPNKKKHK
AIQLIFVVMI VFFIFWTPYN LVLLLSAFHS TFLETSCQQS IHLDLAMQVT EVITHTHCCI
NPIIYAFVGE RFRKHLRLFF HRNVAIYLRK YISFLPGEKL ERTSSVSPST GEQEISVVF
