CCR4F_ARATH
ID CCR4F_ARATH Reviewed; 754 AA.
AC Q8VYU4; Q9LFM2;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Carbon catabolite repressor protein 4 homolog 6;
DE Short=CCR4 homolog 6;
DE EC=3.1.13.4;
GN Name=CCR4-6; OrderedLocusNames=At5g11350; ORFNames=F2I11_240;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Acts as catalytic component of the CCR4-NOT core complex,
CC which in the nucleus seems to be a general transcription factor, and in
CC the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SUBUNIT: Component of the CCR4-NOT complex, at least composed of CRR4
CC and CAF1 proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CCR4/nocturin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB96670.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL360314; CAB96670.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91664.1; -; Genomic_DNA.
DR EMBL; AY069916; AAL47464.1; -; mRNA.
DR EMBL; AY143977; AAN28916.1; -; mRNA.
DR RefSeq; NP_196696.2; NM_121173.5.
DR AlphaFoldDB; Q8VYU4; -.
DR SMR; Q8VYU4; -.
DR STRING; 3702.AT5G11350.1; -.
DR iPTMnet; Q8VYU4; -.
DR PaxDb; Q8VYU4; -.
DR PRIDE; Q8VYU4; -.
DR EnsemblPlants; AT5G11350.1; AT5G11350.1; AT5G11350.
DR GeneID; 831006; -.
DR Gramene; AT5G11350.1; AT5G11350.1; AT5G11350.
DR KEGG; ath:AT5G11350; -.
DR Araport; AT5G11350; -.
DR TAIR; locus:2832132; AT5G11350.
DR eggNOG; KOG2338; Eukaryota.
DR HOGENOM; CLU_008664_0_0_1; -.
DR InParanoid; Q8VYU4; -.
DR PhylomeDB; Q8VYU4; -.
DR PRO; PR:Q8VYU4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8VYU4; baseline and differential.
DR Genevisible; Q8VYU4; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.10.10; -; 2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Exonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease;
KW Nucleus; Reference proteome; Repeat; RNA-binding; Transcription;
KW Transcription regulation.
FT CHAIN 1..754
FT /note="Carbon catabolite repressor protein 4 homolog 6"
FT /id="PRO_0000355049"
FT REGION 34..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 237
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250|UniProtKB:O95551"
FT CONFLICT 291
FT /note="G -> R (in Ref. 3; AAN28916/AAL47464)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 754 AA; 84925 MW; B53A55C92AC288CF CRC64;
MRRSRFVAQV FSDVTFADAS TISAPIFTMS TRAPYRGARG RGRGRGGRSF SDRPYNDDAG
RDQFVTGDSH FQSVHDANFR FRHGEPYRQH QPPLDQRQQP PFNQNYEFRP PPPSRGQWQQ
FRQPNQFPSN QNYAACPPPP FYQNQMSRPP PQQSFRQRPR SKPSDYREWE YAKTPPSPGS
EKFVVLSYNI LADYLANDHW RSLYFHIPRN MLSWGWRKSK LVFELSLWSA DIMCLQEVDK
FQDLEEEMKH RGYSAIWKMR TGNAVDGCAI FWRSNRFKLV HEESIQFNQL GLRDNVAQIC
VLETLLTSHT KENETPPPES SAGSHRVVIC NIHVLFNPKR GDFKLGQVRT LLDKAHAVSK
LWDDAPIVLC GDFNCTPKSP LYNFISDRKL DLSGLARDKV SGQVSAEFRP PRPENYTTRY
QSANKSPQGQ VQPPNLITNA HMENNSNIDV GTAPSEKTSE LPCGDTILAG HEATSSSDQV
LPCENMASDC QFGIENRKPD DSGNLSTAED LSSLTISDTE PQHASSARED LNTDRSVSSG
LSETEQTPEE ICSSDQDISS SLSTKVDTFV AEMKLDGLKL DEPVVFAQDE ESLGEDGETF
LAKLHDNNEN LSQKGELVSE VPLKWSSEAL NSDKITYSPS SWTPMEIATA TGDPERTTVE
HALELKSTYS EVEGQANTRD ENGEPVVTSY HRCFMGTVDY IWRSEGLQTV RVLAPIPKQA
MQWTPGFPTP KWGSDHIALV SELAFCSSKT LPKS
