CCR4_MOUSE
ID CCR4_MOUSE Reviewed; 360 AA.
AC P51680; Q14A03;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=C-C chemokine receptor type 4;
DE Short=C-C CKR-4;
DE Short=CC-CKR-4;
DE Short=CCR-4;
DE Short=CCR4;
DE AltName: CD_antigen=CD194;
GN Name=Ccr4; Synonyms=Cmkbr4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6 X CBA; TISSUE=Thymus;
RX PubMed=8573157; DOI=10.1006/bbrc.1996.0059;
RA Hoogewerf A.J., Black D., Proudfoot A.E.I., Wells T.N.C., Power C.A.;
RT "Molecular cloning of murine CC CKR-4 and high affinity binding of
RT chemokines to murine and human CC CKR-4.";
RL Biochem. Biophys. Res. Commun. 218:337-343(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cytotoxic T-cell;
RX PubMed=9192769;
RA Youn B.-S., Kim S.-H., Lyu M.S., Kozak C.A., Taub D.D., Kwon B.S.;
RT "Molecular cloning and characterization of a cDNA, CHEMR1, encoding a
RT chemokine receptor with a homology to the human C-C chemokine receptor,
RT CCR-4.";
RL Blood 89:4448-4460(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION.
RX PubMed=10811868; DOI=10.1084/jem.191.10.1755;
RA Buser R., Conquet F., Proudfoot A.E.I., Wells T.N.C., Power C.A.;
RT "A key role for CC chemokine receptor 4 in lipopolysaccharide-induced
RT endotoxic shock.";
RL J. Exp. Med. 191:1755-1764(2000).
CC -!- FUNCTION: High affinity receptor for the C-C type chemokines CCL17/TARC
CC and CCL22/MDC. The activity of this receptor is mediated by G(i)
CC proteins which activate a phosphatidylinositol-calcium second messenger
CC system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic
CC shock. In the CNS, could mediate hippocampal-neuron survival.
CC {ECO:0000269|PubMed:10811868}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the thymus, macrophages and T- and B-
CC cells.
CC -!- DEVELOPMENTAL STAGE: Low expression at 7.5 dpc and 12.5 dpc in the yolk
CC sac.
CC -!- PTM: In natural killer cells, CCL22 binding induces phosphorylation on
CC yet undefined Ser/Thr residues, most probably by beta-adrenergic
CC receptor kinases 1 and 2. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X90862; CAA62372.1; -; mRNA.
DR EMBL; U15208; AAA92582.1; -; mRNA.
DR EMBL; CH466587; EDL09307.1; -; Genomic_DNA.
DR EMBL; CH466587; EDL09308.1; -; Genomic_DNA.
DR EMBL; BC117041; AAI17042.1; -; mRNA.
DR EMBL; BC119171; AAI19172.1; -; mRNA.
DR CCDS; CCDS23594.1; -.
DR PIR; JC4587; JC4587.
DR RefSeq; NP_034046.2; NM_009916.2.
DR RefSeq; XP_006511996.1; XM_006511933.2.
DR RefSeq; XP_006511997.1; XM_006511934.3.
DR RefSeq; XP_011241235.1; XM_011242933.2.
DR AlphaFoldDB; P51680; -.
DR SMR; P51680; -.
DR IntAct; P51680; 3.
DR STRING; 10090.ENSMUSP00000062677; -.
DR BindingDB; P51680; -.
DR ChEMBL; CHEMBL5410; -.
DR GuidetoPHARMACOLOGY; 61; -.
DR GlyGen; P51680; 3 sites.
DR PhosphoSitePlus; P51680; -.
DR EPD; P51680; -.
DR PaxDb; P51680; -.
DR PRIDE; P51680; -.
DR ProteomicsDB; 281345; -.
DR Antibodypedia; 11668; 684 antibodies from 38 providers.
DR DNASU; 12773; -.
DR Ensembl; ENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898.
DR Ensembl; ENSMUST00000215425; ENSMUSP00000150002; ENSMUSG00000047898.
DR GeneID; 12773; -.
DR KEGG; mmu:12773; -.
DR UCSC; uc009rxo.2; mouse.
DR CTD; 1233; -.
DR MGI; MGI:107824; Ccr4.
DR VEuPathDB; HostDB:ENSMUSG00000047898; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P51680; -.
DR OMA; FHTQSTG; -.
DR OrthoDB; 900867at2759; -.
DR PhylomeDB; P51680; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 12773; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Ccr4; mouse.
DR PRO; PR:P51680; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P51680; protein.
DR Bgee; ENSMUSG00000047898; Expressed in thymus and 48 other tissues.
DR ExpressionAtlas; P51680; baseline and differential.
DR Genevisible; P51680; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IMP:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IMP:MGI.
DR GO; GO:0048872; P:homeostasis of number of cells; IMP:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR GO; GO:1904936; P:interneuron migration; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0050927; P:positive regulation of positive chemotaxis; ISO:MGI.
DR GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR GO; GO:0009314; P:response to radiation; IEA:Ensembl.
DR GO; GO:0002507; P:tolerance induction; IMP:MGI.
DR InterPro; IPR002239; Chemokine_CCR4.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF608; PTHR10489:SF608; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01109; CHEMOKINER4.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..360
FT /note="C-C chemokine receptor type 4"
FT /id="PRO_0000069246"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 4
FT /note="T -> I (in Ref. 2; AAA92582)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="S -> T (in Ref. 2; AAA92582)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="E -> Q (in Ref. 2; AAA92582)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="E -> D (in Ref. 2; AAA92582)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="C -> W (in Ref. 1; CAA62372)"
FT /evidence="ECO:0000305"
FT CONFLICT 241
FT /note="V -> L (in Ref. 2; AAA92582)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="A -> G (in Ref. 1; CAA62372)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="A -> G (in Ref. 1; CAA62372)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="F -> S (in Ref. 2; AAA92582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 360 AA; 41408 MW; 8FA760951BE2002B CRC64;
MNATEVTDTT QDETVYNSYY FYESMPKPCT KEGIKAFGEV FLPPLYSLVF LLGLFGNSVV
VLVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA DQWVFGLGLC KIVSWMYLVG
FYSGIFFIML MSIDRYLAIV HAVFSLKART LTYGVITSLI TWSVAVFASL PGLLFSTCYT
EHNHTYCKTQ YSVNSTTWKV LSSLEINVLG LLIPLGIMLF CYSMIIRTLQ HCKNEKKNRA
VRMIFAVVVL FLGFWTPYNV VLFLETLVEL EVLQDCTLER YLDYAIQATE TLAFIHCCLN
PVIYFFLGEK FRKYITQLFR TCRGPLVLCK HCDFLQVYSA DMSSSSYTQS TVDHDFRDAL
