ID   CCR8_MACMU              Reviewed;         356 AA.
AC   O97665;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=C-C chemokine receptor type 8;
DE            Short=C-C CKR-8;
DE            Short=CC-CKR-8;
DE            Short=CCR-8;
DE   AltName: CD_antigen=CDw198;
GN   Name=CCR8;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Spleen;
RX   PubMed=11461684; DOI=10.1089/088922201750290104;
RA   Margulies B.J., Hauer D.A., Clements J.E.;
RT   "Identification and comparison of eleven rhesus macaque chemokine
RT   receptors.";
RL   AIDS Res. Hum. Retroviruses 17:981-986(2001).
CC   -!- FUNCTION: Receptor for the chemokines CCL1/SCYA1/I-309. May regulate
CC       monocyte chemotaxis and thymic cell line apoptosis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF100205; AAC72403.1; -; Genomic_DNA.
DR   AlphaFoldDB; O97665; -.
DR   SMR; O97665; -.
DR   STRING; 9544.ENSMMUP00000030243; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; O97665; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR004068; Chemokine_CCR8.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01530; CHEMOKINER8.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..356
FT                   /note="C-C chemokine receptor type 8"
FT                   /id="PRO_0000069289"
FT   TOPO_DOM        1..35
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..63
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..73
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..93
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..172
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        173..203
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..223
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..264
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..281
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..305
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..356
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        106..184
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   356 AA;  41211 MW;  1979628DEE44845B CRC64;
     MDYTLDPSMT TMTDYYYPDS LSSPCDGELI QRNDKLLLAV FYCLLFVFSL LGNSLVILVL
     VVCKKLRNIT DIYLLNLALS DLLFVFSFPF QTYYQLDQWV FGTVMCKVVS GFYYIGFYSS
     MFFITLMSVD RYLAVVHAVY AIKVRTIRMG TTTLSLLVWL TAIMATIPLL VFYQVASEDG
     VLQCYSFYNQ QTLKWKIFTN FEMNILGLLI PFTIFMFCYI KILHQLKRCQ NHNKTKAIRL
     VLIVVIASLL FWVPFNVVLF LTSLHSMHIL DGCSISQQLN YATHVTEIIS FTHCCVNPVI
     YAFVGEKFKK HLSEIFQKSC SHIFIYLGRQ MPRESCEKSS SCQQHSFRSS SIDYIL