CCR8_MOUSE
ID CCR8_MOUSE Reviewed; 353 AA.
AC P56484;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=C-C chemokine receptor type 8;
DE Short=C-C CKR-8;
DE Short=CC-CKR-8;
DE Short=CCR-8;
DE AltName: CD_antigen=CDw198;
GN Name=Ccr8; Synonyms=Cmkbr8, Ter1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=9469461;
RA Goya I., Gutierrez J., Varona R., Kremer L., Zaballos A., Marquez G.;
RT "Identification of CCR8 as the specific receptor for the human beta-
RT chemokine I-309: cloning and molecular characterization of murine CCR8 as
RT the receptor for TCA-3.";
RL J. Immunol. 160:1975-1981(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=9670926;
RA Zingoni A., Soto H., Hedrick J.A., Stoppacciaro A., Storlazzi C.T.,
RA Sinigaglia F., D'Ambrosio D., O'Garra A., Robinson D., Rocchi M.,
RA Santoni A., Zlotnik A., Napolitano M.;
RT "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1
RT cells.";
RL J. Immunol. 161:547-551(1998).
CC -!- FUNCTION: Receptor for the CCL1/SCY1/TCA-3 chemokine.
CC {ECO:0000269|PubMed:9469461}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in thymus. {ECO:0000269|PubMed:9469461}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z98206; CAB10896.1; -; Genomic_DNA.
DR EMBL; Z98205; CAB10895.1; -; mRNA.
DR EMBL; AF001277; AAC97598.1; -; Genomic_DNA.
DR CCDS; CCDS23621.1; -.
DR RefSeq; NP_031746.1; NM_007720.2.
DR AlphaFoldDB; P56484; -.
DR SMR; P56484; -.
DR BioGRID; 198776; 1.
DR STRING; 10090.ENSMUSP00000038473; -.
DR ChEMBL; CHEMBL1075278; -.
DR GuidetoPHARMACOLOGY; 65; -.
DR GlyGen; P56484; 1 site.
DR PhosphoSitePlus; P56484; -.
DR PaxDb; P56484; -.
DR PRIDE; P56484; -.
DR Antibodypedia; 12174; 545 antibodies from 38 providers.
DR DNASU; 12776; -.
DR Ensembl; ENSMUST00000048777; ENSMUSP00000038473; ENSMUSG00000042262.
DR GeneID; 12776; -.
DR KEGG; mmu:12776; -.
DR UCSC; uc009sca.1; mouse.
DR CTD; 1237; -.
DR MGI; MGI:1201402; Ccr8.
DR VEuPathDB; HostDB:ENSMUSG00000042262; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; P56484; -.
DR OMA; CQNHNKT; -.
DR OrthoDB; 900867at2759; -.
DR PhylomeDB; P56484; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 12776; 2 hits in 73 CRISPR screens.
DR PRO; PR:P56484; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P56484; protein.
DR Bgee; ENSMUSG00000042262; Expressed in morula and 39 other tissues.
DR ExpressionAtlas; P56484; baseline and differential.
DR Genevisible; P56484; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR004068; Chemokine_CCR8.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01530; CHEMOKINER8.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..353
FT /note="C-C chemokine receptor type 8"
FT /id="PRO_0000069290"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..61
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..71
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 353 AA; 40045 MW; 31EC4B642CDB9AE5 CRC64;
MDYTMEPNVT MTDYYPDFFT APCDAEFLLR GSMLYLAILY CVLFVLGLLG NSLVILVLVG
CKKLRSITDI YLLNLAASDL LFVLSIPFQT HNLLDQWVFG TAMCKVVSGL YYIGFFSSMF
FITLMSVDRY LAIVHAVYAI KVRTASVGTA LSLTVWLAAV TATIPLMVFY QVASEDGMLQ
CFQFYEEQSL RWKLFTHFEI NALGLLLPFA ILLFCYVRIL QQLRGCLNHN RTRAIKLVLT
VVIVSLLFWV PFNVALFLTS LHDLHILDGC ATRQRLALAI HVTEVISFTH CCVNPVIYAF
IGEKFKKHLM DVFQKSCSHI FLYLGRQMPV GALERQLSSN QRSSHSSTLD DIL
