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CCR9_HUMAN
ID   CCR9_HUMAN              Reviewed;         369 AA.
AC   P51686; Q4VBM3; Q549E0; Q9UQQ6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 2.
DT   03-AUG-2022, entry version 182.
DE   RecName: Full=C-C chemokine receptor type 9;
DE            Short=C-C CKR-9;
DE            Short=CC-CKR-9;
DE            Short=CCR-9;
DE   AltName: Full=G-protein coupled receptor 28;
DE   AltName: Full=GPR-9-6;
DE   AltName: CD_antigen=CDw199;
GN   Name=CCR9; Synonyms=GPR28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=10229797;
RA   Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.;
RT   "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the
RT   receptor for the chemokine TECK.";
RL   J. Immunol. 162:5671-5675(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP   FUNCTION.
RX   PubMed=10640743; DOI=10.4049/jimmunol.164.3.1293;
RA   Yu C.-R., Peden K.W.C., Zaitseva M.B., Golding H., Farber J.M.;
RT   "CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15
RT   that differ in their sensitivities to ligand.";
RL   J. Immunol. 164:1293-1305(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
RA   Lautens L.L., Tiffany H.L., Gao J.-L., Modi W., Murphy P.M., Bonner T.I.;
RT   "Cloning, tissue distribution and chromosomal localization of two potential
RT   G-protein-linked chemokine receptors.";
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Warren C.N., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 24-341, SUBCELLULAR LOCATION, AND
RP   DISULFIDE BOND.
RX   PubMed=27926729; DOI=10.1038/nature20606;
RA   Oswald C., Rappas M., Kean J., Dore A.S., Errey J.C., Bennett K.,
RA   Deflorian F., Christopher J.A., Jazayeri A., Mason J.S., Congreve M.,
RA   Cooke R.M., Marshall F.H.;
RT   "Intracellular allosteric antagonism of the CCR9 receptor.";
RL   Nature 540:462-465(2016).
CC   -!- FUNCTION: Receptor for chemokine SCYA25/TECK. Subsequently transduces a
CC       signal by increasing the intracellular calcium ions level.
CC       {ECO:0000269|PubMed:10229797, ECO:0000269|PubMed:10640743}.
CC   -!- FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for
CC       HIV-1 infection.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27926729};
CC       Multi-pass membrane protein {ECO:0000305|PubMed:27926729}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=CCR9A;
CC         IsoId=P51686-1; Sequence=Displayed;
CC       Name=2; Synonyms=CCR9B;
CC         IsoId=P51686-2; Sequence=VSP_020286;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the thymus and low in lymph
CC       nodes and spleen. {ECO:0000269|PubMed:10229797,
CC       ECO:0000269|PubMed:10640743}.
CC   -!- MISCELLANEOUS: EC50 of SCYA25/TECK for isoform 1 is lower than for
CC       isoform 2.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95516.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=CC chemokine receptors entry;
CC       URL="https://en.wikipedia.org/wiki/CC_chemokine_receptors";
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/CCR9ID44380ch3p21.html";
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DR   EMBL; AJ132337; CAB43477.1; -; mRNA.
DR   EMBL; AF145439; AAF66699.1; -; mRNA.
DR   EMBL; AF145440; AAF66700.1; -; mRNA.
DR   EMBL; U45982; AAA93319.1; -; Genomic_DNA.
DR   EMBL; AY242127; AAO92294.1; -; Genomic_DNA.
DR   EMBL; BC069678; AAH69678.1; -; mRNA.
DR   EMBL; BC095516; AAH95516.1; ALT_INIT; mRNA.
DR   CCDS; CCDS2732.1; -. [P51686-1]
DR   CCDS; CCDS2733.1; -. [P51686-2]
DR   RefSeq; NP_001243298.1; NM_001256369.1. [P51686-2]
DR   RefSeq; NP_006632.2; NM_006641.3. [P51686-2]
DR   RefSeq; NP_112477.1; NM_031200.2. [P51686-1]
DR   RefSeq; XP_011531614.1; XM_011533312.2. [P51686-1]
DR   PDB; 5LWE; X-ray; 2.80 A; A/B=24-341.
DR   PDBsum; 5LWE; -.
DR   AlphaFoldDB; P51686; -.
DR   SMR; P51686; -.
DR   BioGRID; 116017; 18.
DR   DIP; DIP-5884N; -.
DR   IntAct; P51686; 18.
DR   MINT; P51686; -.
DR   STRING; 9606.ENSP00000350256; -.
DR   BindingDB; P51686; -.
DR   ChEMBL; CHEMBL5815; -.
DR   DrugBank; DB15250; Vercirnon.
DR   GuidetoPHARMACOLOGY; 66; -.
DR   GlyGen; P51686; 1 site.
DR   iPTMnet; P51686; -.
DR   PhosphoSitePlus; P51686; -.
DR   BioMuta; CCR9; -.
DR   DMDM; 114152781; -.
DR   PaxDb; P51686; -.
DR   PeptideAtlas; P51686; -.
DR   PRIDE; P51686; -.
DR   ProteomicsDB; 56370; -. [P51686-1]
DR   ProteomicsDB; 56371; -. [P51686-2]
DR   Antibodypedia; 3479; 639 antibodies from 36 providers.
DR   DNASU; 10803; -.
DR   Ensembl; ENST00000357632.7; ENSP00000350256.2; ENSG00000173585.17. [P51686-1]
DR   Ensembl; ENST00000395963.2; ENSP00000379292.2; ENSG00000173585.17. [P51686-2]
DR   GeneID; 10803; -.
DR   KEGG; hsa:10803; -.
DR   MANE-Select; ENST00000357632.7; ENSP00000350256.2; NM_031200.3; NP_112477.1.
DR   UCSC; uc003coz.3; human. [P51686-1]
DR   CTD; 10803; -.
DR   DisGeNET; 10803; -.
DR   GeneCards; CCR9; -.
DR   HGNC; HGNC:1610; CCR9.
DR   HPA; ENSG00000173585; Tissue enriched (lymphoid).
DR   MIM; 604738; gene.
DR   neXtProt; NX_P51686; -.
DR   OpenTargets; ENSG00000173585; -.
DR   PharmGKB; PA26174; -.
DR   VEuPathDB; HostDB:ENSG00000173585; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01030000234667; -.
DR   HOGENOM; CLU_009579_8_3_1; -.
DR   InParanoid; P51686; -.
DR   OMA; TICTMVY; -.
DR   OrthoDB; 800663at2759; -.
DR   PhylomeDB; P51686; -.
DR   TreeFam; TF330966; -.
DR   PathwayCommons; P51686; -.
DR   Reactome; R-HSA-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   SignaLink; P51686; -.
DR   SIGNOR; P51686; -.
DR   BioGRID-ORCS; 10803; 4 hits in 1065 CRISPR screens.
DR   GeneWiki; CCR9; -.
DR   GenomeRNAi; 10803; -.
DR   Pharos; P51686; Tchem.
DR   PRO; PR:P51686; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; P51686; protein.
DR   Bgee; ENSG00000173585; Expressed in thymus and 78 other tissues.
DR   ExpressionAtlas; P51686; baseline and differential.
DR   Genevisible; P51686; HS.
DR   GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR   GO; GO:0004950; F:chemokine receptor activity; TAS:ProtInc.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0002305; P:CD8-positive, gamma-delta intraepithelial T cell differentiation; IEA:Ensembl.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
DR   GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR004069; Chemokine_CCR9.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01531; CHEMOKINER9.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cell membrane; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Host-virus interaction; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..369
FT                   /note="C-C chemokine receptor type 9"
FT                   /id="PRO_0000069291"
FT   TOPO_DOM        1..48
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        49..74
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        75..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        86..109
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        110..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        121..150
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        151..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        160..185
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        186..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        209..243
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        244..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        249..283
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        284..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TRANSMEM        291..321
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   TOPO_DOM        322..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:27926729"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        38..289
FT                   /evidence="ECO:0000269|PubMed:27926729"
FT   DISULFID        119..198
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521,
FT                   ECO:0000269|PubMed:27926729, ECO:0007744|PDB:5LWE"
FT   VAR_SEQ         1..12
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10640743,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|Ref.4"
FT                   /id="VSP_020286"
FT   VARIANT         92
FT                   /note="I -> V (in dbSNP:rs45530037)"
FT                   /id="VAR_029208"
FT   VARIANT         284
FT                   /note="M -> V (in dbSNP:rs12721497)"
FT                   /id="VAR_020068"
FT   HELIX           33..37
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           45..75
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           82..106
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           117..148
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           151..154
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           155..157
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           158..179
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           181..185
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           209..222
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           224..243
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           249..252
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           254..282
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           289..307
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           308..311
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           313..320
FT                   /evidence="ECO:0007829|PDB:5LWE"
FT   HELIX           324..341
FT                   /evidence="ECO:0007829|PDB:5LWE"
SQ   SEQUENCE   369 AA;  42016 MW;  F27CEA0CFB66B44C CRC64;
     MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF LPPLYWLVFI
     VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT LPFWAIAAAD QWKFQTFMCK
     VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ AMRAHTWREK RLLYSKMVCF TIWVLAAALC
     IPEILYSQIK EESGIAICTM VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT
     LIQAKKSSKH KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ
     VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE GSLKLSSMLL
     ETTSGALSL
 
 
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