CCR9_MOUSE
ID CCR9_MOUSE Reviewed; 369 AA.
AC Q9WUT7; A2RSM5; Q543I4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=C-C chemokine receptor type 9;
DE Short=C-C CKR-9;
DE Short=CC-CKR-9;
DE Short=CCR-9;
DE AltName: Full=Chemokine C-C receptor 10;
DE AltName: CD_antigen=CDw199;
GN Name=Ccr9; Synonyms=Cmkbr10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thymus;
RX PubMed=10229797;
RA Zaballos A., Gutierrez J., Varona R., Ardavin C., Marquez G.;
RT "Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the
RT receptor for the chemokine TECK.";
RL J. Immunol. 162:5671-5675(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10602049;
RX DOI=10.1002/1521-4141(200001)30:1<262::aid-immu262>3.0.co;2-0;
RA Wurbel M.A., Philippe J.-M., Nguyen C., Victorero G., Freeman T.,
RA Wooding P., Miazek A., Mattei M.-G., Malissen M., Jordan B.R., Malissen B.,
RA Carrier A., Naquet P.;
RT "The chemokine TECK is expressed by thymic and intestinal epithelial cells
RT and attracts double- and single-positive thymocytes expressing the TECK
RT receptor CCR9.";
RL Eur. J. Immunol. 30:262-271(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Skin, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for chemokine SCYA25/TECK. Subsequently transduces a
CC signal by increasing the intracellular calcium ions level.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51686};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P51686}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the thymus and low in lymph
CC nodes and spleen.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ132336; CAB43480.1; -; mRNA.
DR EMBL; AJ131357; CAB66136.2; -; mRNA.
DR EMBL; AK019478; BAB31747.1; -; mRNA.
DR EMBL; AK050615; BAC34344.1; -; mRNA.
DR EMBL; AK153975; BAE32291.1; -; mRNA.
DR EMBL; BC132166; AAI32167.1; -; mRNA.
DR EMBL; BC132466; AAI32467.1; -; mRNA.
DR CCDS; CCDS23662.1; -.
DR RefSeq; NP_001160097.1; NM_001166625.1.
DR RefSeq; NP_034043.1; NM_009913.6.
DR AlphaFoldDB; Q9WUT7; -.
DR SMR; Q9WUT7; -.
DR BioGRID; 198769; 1.
DR DIP; DIP-5886N; -.
DR STRING; 10090.ENSMUSP00000127024; -.
DR GlyGen; Q9WUT7; 1 site.
DR iPTMnet; Q9WUT7; -.
DR PhosphoSitePlus; Q9WUT7; -.
DR jPOST; Q9WUT7; -.
DR PaxDb; Q9WUT7; -.
DR PRIDE; Q9WUT7; -.
DR ProteomicsDB; 281130; -.
DR Antibodypedia; 3479; 639 antibodies from 36 providers.
DR DNASU; 12769; -.
DR Ensembl; ENSMUST00000163559; ENSMUSP00000131782; ENSMUSG00000029530.
DR Ensembl; ENSMUST00000166236; ENSMUSP00000127024; ENSMUSG00000029530.
DR Ensembl; ENSMUST00000168910; ENSMUSP00000126758; ENSMUSG00000029530.
DR Ensembl; ENSMUST00000180093; ENSMUSP00000137144; ENSMUSG00000029530.
DR GeneID; 12769; -.
DR KEGG; mmu:12769; -.
DR UCSC; uc009sgl.2; mouse.
DR CTD; 10803; -.
DR MGI; MGI:1341902; Ccr9.
DR VEuPathDB; HostDB:ENSMUSG00000029530; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234667; -.
DR InParanoid; Q9WUT7; -.
DR OMA; TICTMVY; -.
DR OrthoDB; 800663at2759; -.
DR PhylomeDB; Q9WUT7; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 12769; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ccr9; mouse.
DR PRO; PR:Q9WUT7; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9WUT7; protein.
DR Bgee; ENSMUSG00000029530; Expressed in thymus and 88 other tissues.
DR ExpressionAtlas; Q9WUT7; baseline and differential.
DR Genevisible; Q9WUT7; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IDA:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0002305; P:CD8-positive, gamma-delta intraepithelial T cell differentiation; IMP:MGI.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006935; P:chemotaxis; IDA:MGI.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR004069; Chemokine_CCR9.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01531; CHEMOKINER9.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..369
FT /note="C-C chemokine receptor type 9"
FT /id="PRO_0000069292"
FT TOPO_DOM 1..48
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 49..74
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 75..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 86..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 110..120
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 121..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 151..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 160..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 186..208
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 209..243
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 244..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 249..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 284..290
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 291..321
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 322..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 38..289
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT DISULFID 119..198
FT /evidence="ECO:0000250|UniProtKB:P51686,
FT ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 369 AA; 41913 MW; 6971F76F0A24B4AE CRC64;
MMPTELTSLI PGMFDDFSYD STASTDDYMN LNFSSFFCKK NNVRQFASHF LPPLYWLVFI
VGTLGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLAT LPFWAIAAAG QWMFQTFMCK
VVNSMYKMNF YSCVLLIMCI SVDRYIAIVQ AMKAQVWRQK RLLYSKMVCI TIWVMAAVLC
TPEILYSQVS GESGIATCTM VYPKDKNAKL KSAVLILKVT LGFFLPFMVM AFCYTIIIHT
LVQAKKSSKH KALKVTITVL TVFIMSQFPY NSILVVQAVD AYAMFISNCT ISTNIDICFQ
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE GSLKLSSMLL
ETTSGALSL
