CCR9_SHEEP
ID CCR9_SHEEP Reviewed; 367 AA.
AC Q1WLP9;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=C-C chemokine receptor type 9;
DE Short=C-C CKR-9;
DE Short=CC-CKR-9;
DE Short=CCR-9;
DE AltName: CD_antigen=CDw199;
GN Name=CCR9;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Peyer patch;
RA Meurens F., Whale J., Brownlie R., Gerdts V.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for chemokine SCYA25/TECK. Subsequently transduces a
CC signal by increasing the intracellular calcium ions level (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51686};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P51686}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; DQ131911; ABA00206.1; -; mRNA.
DR RefSeq; NP_001035376.1; NM_001040286.1.
DR RefSeq; XP_011954646.1; XM_012099256.2.
DR AlphaFoldDB; Q1WLP9; -.
DR SMR; Q1WLP9; -.
DR STRING; 9940.ENSOARP00000010208; -.
DR Ensembl; ENSOART00000010357; ENSOARP00000010208; ENSOARG00000009514.
DR Ensembl; ENSOART00020039608; ENSOARP00020032822; ENSOARG00020025255.
DR GeneID; 678667; -.
DR KEGG; oas:678667; -.
DR CTD; 10803; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_8_3_1; -.
DR OMA; TICTMVY; -.
DR OrthoDB; 800663at2759; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000009514; Expressed in major salivary gland and 37 other tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:Ensembl.
DR GO; GO:0002305; P:CD8-positive, gamma-delta intraepithelial T cell differentiation; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR InterPro; IPR004069; Chemokine_CCR9.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01531; CHEMOKINER9.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..367
FT /note="C-C chemokine receptor type 9"
FT /id="PRO_0000249812"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 47..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 73..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 84..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 108..118
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 119..148
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 149..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 158..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 184..206
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 207..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 242..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 247..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 282..288
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TRANSMEM 289..319
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT TOPO_DOM 320..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 36..287
FT /evidence="ECO:0000250|UniProtKB:P51686"
FT DISULFID 117..196
FT /evidence="ECO:0000250|UniProtKB:P51686,
FT ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 367 AA; 41646 MW; 398513645654DB0E CRC64;
MVPTEATSLI LNPSDDYGYD GTPPMEYDTN LTDYFCEKSH VRQFAGHFLP PLYWLVFIVG
AVGNSLVILV YWYCTRVKTM TDMFLLNLAI ADLLFLTTLP FWAIAAADQW KFQTFMCKVV
NSMYKMNFYS CVLLIMCISV DRYIAIAQAM RAQMWRQKRL LYSKMVCFTI WVMAAALCLP
ELLYSQVKEE HGTAICTVVY SSNESTKLKS AVLTLKVTLG FFLPFVVMAC CYAIIIHTLI
RAKKSSKHKA LKVTITVLTV FVLSQFPHNC VLLVQTIDAY ATFISSCALS IKIDICFQVT
QTVAFFHSCL NPVLYVFVGE RFRRDLVKTL KNLGCISQAQ WVSFTRREGS LKLSSMLLET
TSGALSF
