CCRL2_BOVIN
ID CCRL2_BOVIN Reviewed; 348 AA.
AC Q0II78;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Chemokine C-C motif receptor-like 2;
GN Name=CCRL2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for CCL19 and chemerin/RARRES2. Does not appear to
CC be a signaling receptor, but may have a role in modulating chemokine-
CC triggered immune responses by capturing and internalizing CCL19 or by
CC presenting RARRES2 ligand to CMKLR1, a functional signaling receptor.
CC Plays a critical role for the development of Th2 responses (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: Lacks the conserved DRYLAIV motif in the second intracellular
CC loop that is required for signaling of functional chemokine receptors.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC122767; AAI22768.1; -; mRNA.
DR RefSeq; NP_001069200.1; NM_001075732.2.
DR RefSeq; XP_005223117.1; XM_005223060.2.
DR RefSeq; XP_005223118.1; XM_005223061.3.
DR RefSeq; XP_005223119.1; XM_005223062.3.
DR RefSeq; XP_015315153.1; XM_015459667.1.
DR AlphaFoldDB; Q0II78; -.
DR SMR; Q0II78; -.
DR STRING; 9913.ENSBTAP00000008096; -.
DR PaxDb; Q0II78; -.
DR Ensembl; ENSBTAT00000008096; ENSBTAP00000008096; ENSBTAG00000006155.
DR GeneID; 515976; -.
DR KEGG; bta:515976; -.
DR CTD; 9034; -.
DR VEuPathDB; HostDB:ENSBTAG00000006155; -.
DR VGNC; VGNC:26990; CCRL2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q0II78; -.
DR OMA; CKSNYNL; -.
DR OrthoDB; 1277718at2759; -.
DR TreeFam; TF330966; -.
DR Reactome; R-BTA-380108; Chemokine receptors bind chemokines.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000006155; Expressed in milk and 98 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IEA:Ensembl.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..348
FT /note="Chemokine C-C motif receptor-like 2"
FT /id="PRO_0000409374"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..292
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 348 AA; 40061 MW; 8755D916A4743C99 CRC64;
MANYTPAPED DYDVFIEDDL SDDEIEPCTP YDPKILSAQL VPYLYTTVFM VGLLDNILVV
FILVKYKGLR QAENMSFLNL ALSNLGFLLT LPFWAYAASH GEGFDDPLCK ILLLLYSIGL
YSEAFFNVLL TVQRYKEFFH VRRRFSACRT VAGSIFISVL VWVTATLVTL PELVSYKPQM
QSQKYKCFFT GLHFLPADET FWKHFLTLKM NILGFLLPLF AFVYCYVRMR KTLQFRERNY
GLFKLVFTIM AVFLLMWGPY NIVLFLSAFN EHFSLHGCGS SYNLNKSVQI TRIIAATHCC
VNPLLYVFLD KAFRKHLCHL FYLCSDTAPQ PTEEPAQGAS GEEYHLSS
