CCS1_ARATH
ID CCS1_ARATH Reviewed; 547 AA.
AC Q9XIA4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Cytochrome c biogenesis protein CCS1, chloroplastic;
DE AltName: Full=C-type cytochrome synthesis protein 1;
DE Flags: Precursor;
GN Name=CCS1; OrderedLocusNames=At1g49380; ORFNames=F13F21.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Required during biogenesis of c-type cytochromes (cytochrome
CC c6 and cytochrome f) at the step of heme attachment. {ECO:0000250}.
CC -!- SUBUNIT: May interact with ccsA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Ccs1/CcsB family. {ECO:0000305}.
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DR EMBL; AC007504; AAD43162.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32423.1; -; Genomic_DNA.
DR EMBL; AK117293; BAC41965.1; -; mRNA.
DR PIR; B96530; B96530.
DR RefSeq; NP_564544.1; NM_103828.3.
DR AlphaFoldDB; Q9XIA4; -.
DR STRING; 3702.AT1G49380.1; -.
DR iPTMnet; Q9XIA4; -.
DR PaxDb; Q9XIA4; -.
DR PRIDE; Q9XIA4; -.
DR ProteomicsDB; 224383; -.
DR EnsemblPlants; AT1G49380.1; AT1G49380.1; AT1G49380.
DR GeneID; 841361; -.
DR Gramene; AT1G49380.1; AT1G49380.1; AT1G49380.
DR KEGG; ath:AT1G49380; -.
DR Araport; AT1G49380; -.
DR TAIR; locus:2010267; AT1G49380.
DR eggNOG; ENOG502QRFF; Eukaryota.
DR HOGENOM; CLU_034630_0_0_1; -.
DR InParanoid; Q9XIA4; -.
DR OMA; RFWIDYT; -.
DR OrthoDB; 509749at2759; -.
DR PhylomeDB; Q9XIA4; -.
DR PRO; PR:Q9XIA4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIA4; baseline and differential.
DR Genevisible; Q9XIA4; AT.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR HAMAP; MF_01392; CytC_Ccs1; 1.
DR InterPro; IPR023494; Cyt_c_bgen_Ccs1/CcsB/ResB.
DR InterPro; IPR007816; ResB-like_domain.
DR PANTHER; PTHR31566; PTHR31566; 1.
DR Pfam; PF05140; ResB; 2.
PE 1: Evidence at protein level;
KW Chloroplast; Cytochrome c-type biogenesis; Membrane; Plastid;
KW Reference proteome; Thylakoid; Transit peptide; Transmembrane;
KW Transmembrane helix.
FT TRANSIT 1..?
FT /note="Chloroplast"
FT /evidence="ECO:0000305"
FT TRANSIT ?..37
FT /note="Thylakoid"
FT /evidence="ECO:0000305"
FT CHAIN 38..547
FT /note="Cytochrome c biogenesis protein CCS1, chloroplastic"
FT /id="PRO_0000363637"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 41..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 59393 MW; 6920A25C22E29093 CRC64;
MIVTLNPKIL HFSKIHPFSR PSSYLCRTRN VSLITNCKLQ KPQDGNQRSS SNRNLTKTIS
LSDSAPPVTE ETGDGIVKGG GNGGGGGGDG RGGLGFLKIL PRKVLSVLSN LPLAITEMFT
IAALMALGTV IEQGETPDFY FQKYPEDNPV LGFFTWRWIS TLGLDHMYSA PIFLGMLVLL
AASLMACTYT TQIPLVKVAR RWSFMKSDEA IKKQEFADTL PRASIQDLGM ILMGDGFEVF
MKGPSLYAFK GLAGRFAPIG VHIAMLLIMV GGTLSATGSF RGSVTVPQGL NFVMGDVLAP
IGFFSIPTDA FNTEVHVNRF TMDYYDSGEV SQFHSDLSLR DLNGKEVLRK TISVNDPLRY
GGVTVYQTDW SFSALQVTKD GEGPFNLAMA PIKINGDKKL YGTFLPVGDT NAPNVKGISM
LARDLQSIVV YDLDGKFAGI RRPSSKLPIE INGMKIVIED AIGSTGLELK TDPGVPVVYA
GFGALMLTTC ISYLSHSQIW ALQNGTALVV GGKTNRAKNQ FPDDMNRLLD QVPELIKKNT
SVVSEQS
