ID   CCSA_ADICA              Reviewed;         316 AA.
AC   Q85FH6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Cytochrome c biogenesis protein CcsA {ECO:0000255|HAMAP-Rule:MF_01391};
GN   Name=ccsA {ECO:0000255|HAMAP-Rule:MF_01391};
OS   Adiantum capillus-veneris (Maidenhair fern).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Polypodiopsida; Polypodiidae; Polypodiales; Pteridineae; Pteridaceae;
OC   Vittarioideae; Adiantum.
OX   NCBI_TaxID=13818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12755170; DOI=10.1093/dnares/10.2.59;
RA   Wolf P.G., Rowe C.A., Sinclair R.B., Hasebe M.;
RT   "Complete nucleotide sequence of the chloroplast genome from a
RT   leptosporangiate fern, Adiantum capillus-veneris L.";
RL   DNA Res. 10:59-65(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND RNA EDITING.
RC   TISSUE=Frond;
RX   PubMed=15363849; DOI=10.1016/j.gene.2004.06.018;
RA   Wolf P.G., Rowe C.A., Hasebe M.;
RT   "High levels of RNA editing in a vascular plant chloroplast genome:
RT   analysis of transcripts from the fern Adiantum capillus-veneris.";
RL   Gene 339:89-97(2004).
CC   -!- FUNCTION: Required during biogenesis of c-type cytochromes (cytochrome
CC       c6 and cytochrome f) at the step of heme attachment.
CC       {ECO:0000255|HAMAP-Rule:MF_01391}.
CC   -!- SUBUNIT: May interact with Ccs1. {ECO:0000255|HAMAP-Rule:MF_01391}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC       {ECO:0000255|HAMAP-Rule:MF_01391}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01391}.
CC   -!- RNA EDITING: Modified_positions=1 {ECO:0000269|PubMed:15363849}, 2
CC       {ECO:0000269|PubMed:15363849}, 86 {ECO:0000269|PubMed:15363849}, 114
CC       {ECO:0000269|PubMed:15363849}, 130 {ECO:0000269|PubMed:15363849}, 137
CC       {ECO:0000269|PubMed:15363849}, 149 {ECO:0000269|PubMed:15363849}, 154
CC       {ECO:0000269|PubMed:15363849}, 247 {ECO:0000269|PubMed:15363849}, 264
CC       {ECO:0000269|PubMed:15363849}, 269 {ECO:0000269|PubMed:15363849}, 286
CC       {ECO:0000269|PubMed:15363849}; Note=The initiator methionine is created
CC       by RNA editing.;
CC   -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01391}.
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DR   EMBL; AY178864; AAP29440.2; -; Genomic_DNA.
DR   RefSeq; NP_848109.2; NC_004766.1.
DR   AlphaFoldDB; Q85FH6; -.
DR   SMR; Q85FH6; -.
DR   GeneID; 807443; -.
DR   GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01391; CytC_CcsA; 1.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR017562; Cyt_c_biogenesis_CcsA.
DR   InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR   PANTHER; PTHR30071; PTHR30071; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   TIGRFAMs; TIGR03144; cytochr_II_ccsB; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Cytochrome c-type biogenesis; Membrane; Plastid; RNA editing;
KW   Thylakoid; Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Cytochrome c biogenesis protein CcsA"
FT                   /id="PRO_0000201596"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        39..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        257..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
SQ   SEQUENCE   316 AA;  36119 MW;  F41FFD800184889D CRC64;
     MIYTGIEYIF VNISFVMFFF VTLLNLINLF YKIDKIDHFS KNSMTIAFFC TTGFLITRYL
     QTRHLPLGNL YESLMFLSWG FSLLYLILEV RDQIGLSHAV LAPGAMLIHA FATLSLPQQM
     RSPTLLVPAL QSQWLMMHVS AMLISYITLL CGSLLAITLL SLFYGKVGSV TLEHKFEKQS
     FFFLMNPRKN LWKQTGAENY SYFLISNSRK CQLINCLDKW ACQTISLGFS LLTIGILSGA
     VWANEAWGSY WSWDPKETWA LVTWLVYAIY LHTKVDKRKM GEGPAMTASM GFFLVWICFL
     GVNLLGVGLH NYGWLA