ID   CCSA_ANTAG              Reviewed;         339 AA.
AC   Q85A51;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Cytochrome c biogenesis protein CcsA {ECO:0000255|HAMAP-Rule:MF_01391};
GN   Name=ccsA {ECO:0000255|HAMAP-Rule:MF_01391};
OS   Anthoceros angustus (Hornwort) (Anthoceros formosae).
OG   Plastid; Chloroplast.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Anthocerotophyta;
OC   Anthocerotopsida; Anthocerotidae; Anthocerotales; Anthocerotaceae;
OC   Anthoceros.
OX   NCBI_TaxID=48387;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND RNA EDITING.
RX   PubMed=12527781; DOI=10.1093/nar/gkg155;
RA   Kugita M., Kaneko A., Yamamoto Y., Takeya Y., Matsumoto T., Yoshinaga K.;
RT   "The complete nucleotide sequence of the hornwort (Anthoceros formosae)
RT   chloroplast genome: insight into the earliest land plants.";
RL   Nucleic Acids Res. 31:716-721(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND RNA EDITING.
RC   TISSUE=Thallus;
RX   PubMed=12711687; DOI=10.1093/nar/gkg327;
RA   Kugita M., Yamamoto Y., Fujikawa T., Matsumoto T., Yoshinaga K.;
RT   "RNA editing in hornwort chloroplasts makes more than half the genes
RT   functional.";
RL   Nucleic Acids Res. 31:2417-2423(2003).
CC   -!- FUNCTION: Required during biogenesis of c-type cytochromes (cytochrome
CC       c6 and cytochrome f) at the step of heme attachment.
CC       {ECO:0000255|HAMAP-Rule:MF_01391}.
CC   -!- SUBUNIT: May interact with Ccs1. {ECO:0000255|HAMAP-Rule:MF_01391}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC       {ECO:0000255|HAMAP-Rule:MF_01391}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_01391}.
CC   -!- RNA EDITING: Modified_positions=1 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 14 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 60 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 63 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 131 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 161 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 238 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 239 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}, 253 {ECO:0000269|PubMed:12527781,
CC       ECO:0000269|PubMed:12711687}; Note=The initiator methionine is created
CC       by RNA editing. The nonsense codons at positions 238 and 239 are
CC       modified to sense codons.;
CC   -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC       {ECO:0000255|HAMAP-Rule:MF_01391}.
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DR   EMBL; AB086179; BAC55400.1; -; Genomic_DNA.
DR   EMBL; AB087484; BAC55500.1; -; mRNA.
DR   RefSeq; NP_777463.1; NC_004543.1.
DR   AlphaFoldDB; Q85A51; -.
DR   SMR; Q85A51; -.
DR   GeneID; 2553486; -.
DR   GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01391; CytC_CcsA; 1.
DR   InterPro; IPR002541; Cyt_c_assembly.
DR   InterPro; IPR017562; Cyt_c_biogenesis_CcsA.
DR   InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR   PANTHER; PTHR30071; PTHR30071; 1.
DR   Pfam; PF01578; Cytochrom_C_asm; 1.
DR   TIGRFAMs; TIGR03144; cytochr_II_ccsB; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Cytochrome c-type biogenesis; Membrane; Plastid; RNA editing;
KW   Thylakoid; Transmembrane; Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="Cytochrome c biogenesis protein CcsA"
FT                   /id="PRO_0000201597"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT   TRANSMEM        281..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
SQ   SEQUENCE   339 AA;  38304 MW;  E5EA0DC732BF45DC CRC64;
     MILINLEHIL AHISFFLPFL ATLVFWGRIV CIDNKRIGSL GNKSIIIAYI CITGLLLTRW
     FHSRHLLLSN LYESFMFLSW SFCLIHIVSE IGSKNDWLGI IIVLIAMLTH GFATVGLPIE
     MQQSTVLVPA LQSHWLIMHV SMMIPSYATL PCGSLLVIAL LITTLNKNKN FPILKFNVNS
     FIWSLILEKK FYLGGSGGDI SSRNSSSGNG SDNDSNNNNN KKTFHSLSID CRKLQLTQQL
     DYWSYRIISL GSLFLTIGIL SGAVWVNEAW GSYWSWDPKE TWALITWLLS AIHIHIRMIR
     GWQGEKPAII ASSGSSIVWF RYLGVNSPEK GLHSYGWLN